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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Clinical significance of serum concentration of anti-Müllerian hormone in obese women with polycystic ovary syndrome
Reproductive BioMedicine Online, Volume 15, No. 5, Article 2954, Year 2007
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Description
In the human ovary, expression of anti-Müllerian hormone (AMH) is detected primarily in granulosa cells of preantral and small antral follicles. The aim of this study was to compare serum AMH measurements in obese women with polycystic ovary syndrome (PCOS) with those in obese normo-ovulatory women and to evaluate the role of AMH as a predictor of ovulation induction by clomiphene citrate compared to FSH. Sixty-eight obese women with PCOS were compared to 17 normo-ovulatory obese women. All women had a body mass index greater than 30 kg/m2. Women with PCOS received clomiphene citrate (150 mg/day) for 5 days starting from day 3 of cycle and were subdivided into responsive and non-responsive groups. There was a significant difference in AMH concentration between women with PCOS and the control group (P < 0.05) and also between women with PCOS who responded to clorniphene citrate and those who did not (P < 0.01). A value of 1.2 ng/ml AMH could be used to predict response to clomiphene citrate in obese women with PCOS (sensitivity 71%, specificity 65.7%). AMH production increases in women with PCOS, compared to controls. AMH measurement could also be useful in the prediction of ovarian response to clomiphene citrate. © 2007 Published by Reproductive Healthcare Ltd.
Authors & Co-Authors
El-Halawaty, Samir
Egypt, Cairo
Faculty of Medicine
Rezk, Ahmed Y.
Egypt, Benha
Faculty of Medicine
Kamal, Manal Mohamed
Egypt, Giza
Cairo University
AboulHassan, Mona
Egypt, Giza
Cairo University
Al-Sawah, Heba
Egypt, Cairo
Faculty of Medicine
Noah, Olfat
Egypt, Cairo
Faculty of Medicine
Al-Inany, Hesham Gaber
Egypt, Cairo
Faculty of Medicine
Statistics
Citations: 7
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/S1472-6483(10)60379-3
ISSN:
14726483
Research Areas
Health System And Policy
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Participants Gender
Female