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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Immunogenicity for 16 serotypes of a unique schedule of pneumococcal vaccines in a high-risk population
Vaccine, Volume 26, No. 31, Year 2008
Notification
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Description
Background: A unique schedule of 7-valent pneumococcal conjugate vaccine (7PCV) at 2, 4 and 6 months of age and 23-valent pneumococcal polysaccharide vaccine (23PPV) at 18 months commenced for Australian Aboriginal infants in 2001. Methods: Anti-capsular IgG concentrations in vaccinated and non-vaccinated (historic control) infants were determined (blinded) by (22F absorbed) ELISA. Results: One month after dose 3 of 7PCV, geometric mean concentrations (GMCs) were >1.95 μg/ml and at least 89% of infants had IgG >0.35 μg/ml to all 7PCV serotypes. One month post-23PPV, IgG to 7PCV serotypes was >0.35 μg/ml for more than 96% infants (>1.3 μg/ml for at least 70%), and IgG to non-7PCV serotypes was >0.35 μg/ml for more than 50% infants (including serotype 6A, but not 12F (17%) or 19A (44%). Conclusion: 7PCV and 23PPV are immunogenic in this population. © 2008 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Leach, Amanda Jane
Australia, Darwin
Menzies School of Health Research
Morris, Peter Stanley
Australia, Darwin
Menzies School of Health Research
Australia, Adelaide
Flinders University
MacKenzie, Grant Austin
Australia, Darwin
Menzies School of Health Research
Gambia, Banjul
Medical Research Council Laboratories Gambia
McDonnell, Joseph
Australia, Darwin
Menzies School of Health Research
Balloch, Anne
Australia, Melbourne
Murdoch Children's Research Institute
Carapetis, Jonathan Rhys
Australia, Darwin
Menzies School of Health Research
Australia, Adelaide
Flinders University
Tang, Mimi L.K.
Australia, Melbourne
Murdoch Children's Research Institute
Statistics
Citations: 14
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/j.vaccine.2008.05.012
ISSN:
0264410X
Study Design
Cross Sectional Study