Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Chronic pulmonary cavitary tuberculosis in rabbits: A failed host immune response
Open Biology, Volume 1, No. DECEMBER, Article 110016, Year 2011
Notification
URL copied to clipboard!
Description
The molecular determinants of the immune response to Mycobacterium tuberculosis HN878 infection in a rabbit model of pulmonary cavitary tuberculosis were studied. Aerosol infection of rabbits resulted in a highly differentially expressed global transcriptome in the lungs at 2 weeks, which dropped at 4 weeks and then gradually increased. While IFNg was progressively upregulated throughout the infection, several other genes in the IFNg network were not. T-cell activation network genes were gradually upregulated and maximally induced at 12 weeks. Similarly, the IL4 and B-cell activation networks were progressively upregulated, many reaching high levels between 12 and 16 weeks. Delayed peak expression of genes associated with macrophage activation and Th1 type immunity was noted. Although spleen CD4+ and CD8 + T cells showed maximal tuberculosis antigen-specific activation by 8 weeks, macrophage activation in lungs, lymph nodes and spleen did not peak until 12 weeks. In the lungs, infecting bacilli grew exponentially up to 4 weeks, followed by a steady-state high bacillary load to 12 weeks that moderately increased during cavitation at 16 weeks. Thus, the outcome of HN878 infection of rabbits was determined early during infection by a suboptimal activation of innate immunity and delayed T-cell activation. © 2011 The Authors.
Authors & Co-Authors
Subbian, Selvakumar
United States, Newark
Public Health Research Institute
Tsenova, Liana
United States, Newark
Public Health Research Institute
United States, New York
Nyc College of Technology
Yang, Guibin
United States, Newark
Public Health Research Institute
O'Brien, Paul
United States, Newark
Public Health Research Institute
Parsons, Sven D.C.
South Africa, Stellenbosch
Stellenbosch University
Peixoto, Blas
United States, Newark
Public Health Research Institute
Taylor, Leslie M.
United States, Newark
Public Health Research Institute
Fallows, Dorothy A.
United States, Newark
Public Health Research Institute
Kaplan, Gilla
United States, Newark
Public Health Research Institute
Statistics
Citations: 95
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1098/rsob.110016
e-ISSN:
20462441