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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genetic variations of ND5 gene of mtDNA in populations of Anopheles sinensis (Diptera: Culicidae) malaria vector in China
Parasites and Vectors, Volume 6, No. 1, Article 290, Year 2013
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Description
Background: Anopheles sinensis is a principal vector for Plasmodium vivax malaria in most parts of China. Understanding of genetic structure and genetic differentiation of the mosquito should contribute to the vector control and malaria elimination in China. Methods. The present study investigated the genetic structure of An. sinensis populations using a 729 bp fragment of mtDNA ND5 among 10 populations collected from seven provinces in China. Results: ND5 was polymorphic by single mutations within three groups of An. sinensis that were collected from 10 different geographic populations in China. Out of 140 specimens collected from 10 representative sites, 84 haplotypes and 71 variable positions were determined. The overall level of genetic differentiation of An. sinensis varied from low to moderate across China and with a F §ssub§ST§esub§ range of 0.00065 - 0.341. Genealogy analysis clustered the populations of An. sinensis into three main clusters. Each cluster shared one main haplotype. Pairwise variations within populations were higher (68.68%) than among populations (31.32%) and with high fixation index (F §ssub§ST§esub§ = 0.313). The results of the present study support population growth and expansion in the An. sinensis populations from China. Three clusters of An. sinensis populations were detected in this study with each displaying different proportion patterns over seven Chinese provinces. No correlation between genetic and geographic distance was detected in overall populations of An. sinensis (R§ssup§2§esup§ = 0.058; P = 0.301). Conclusions: The results indicate that the ND5 gene of mtDNA is highly polymorphic in An. sinensis and has moderate genetic variability in the populations of this mosquito in China. Demographic and spatial results support evidence of expansion in An. sinensis populations. © 2013 Makhawi et al.; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4228240/bin/1756-3305-6-290-S1.doc
Authors & Co-Authors
Makhawi, Abdelrafie Mohamed
China, Beijing
Chinese Center for Disease Control and Prevention
China, Beijing
Who Collaborating Centre for Vector Surveillance and Management
Sudan, Khartoum
University of Bahri
Liu, Xiao Bo
China, Beijing
Chinese Center for Disease Control and Prevention
China, Beijing
Who Collaborating Centre for Vector Surveillance and Management
China, Hangzhou
The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases
Yang, Shu Ran
China, Beijing
Chinese Center for Disease Control and Prevention
China, Beijing
Who Collaborating Centre for Vector Surveillance and Management
Liu, Qi Yong
China, Beijing
Chinese Center for Disease Control and Prevention
China, Beijing
Who Collaborating Centre for Vector Surveillance and Management
China, Hangzhou
The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases
Statistics
Citations: 24
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1186/1756-3305-6-290
e-ISSN:
17563305
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study