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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Immunologic memory 5 years after meningococcal A/C conjugate vaccination in infancy
Journal of Infectious Diseases, Volume 183, No. 1, Year 2001
Notification
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Description
Infant vaccination with meningococcal conjugates may provide long-term protection against disease. Antibody levels and immunologic memory were assessed in 5-year-old Gambian children who received meningococcal A/C conjugate vaccination (MenA/C) in infancy. At 2 years, they were randomized to receive a booster of MenA/C (conjugate group), meningococcal A/C polysaccharide (MPS group), or inactivated polio vaccine (PV group). All groups were revaccinated with 10 μg MPS at 5 years of age, as were 39 previously unvaccinated age-matched control subjects. Before revaccination, titers were higher in the conjugate and MPS groups than in control subjects (P<.001); titers for the IPV group were similar to those for control subjects. Ten days after revaccination, the conjugate and IPV groups had similar serogroup C serum bactericidal antibody titers (3421 vs. 2790, respectively). These levels were significantly higher than those in the MPS (426) and control (485) groups (P< .001). Thus, immunologic memory was sustained for ≥5 years; however, MPS challenge at 2 years interfered with a subsequent memory response. © Oxford University Press 2001.
Authors & Co-Authors
MacLennan, Jenny M.
Unknown Affiliation
Obaro, Stephen K.
Unknown Affiliation
Deeks, Jonathan J.
Unknown Affiliation
Lake, Derrick
Unknown Affiliation
Elie, Cheryl M.
Unknown Affiliation
Carlone, George M.
Unknown Affiliation
Moxon, E. Richard
Unknown Affiliation
Greenwood, Brian M.
Unknown Affiliation
Statistics
Citations: 106
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1086/317667
ISSN:
00221899
Research Areas
Maternal And Child Health