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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease
Human Molecular Genetics, Volume 17, No. 5, Year 2008
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Description
Late-onset Alzheimer's disease (LOAD) and Parkinson's disease (PD) are the most common neurodegenerative disorders and in both diseases susceptibility is known to be influenced by genes. We set out to identify novel susceptibility genes for LOAD by performing a large scale, multi-tiered association study testing 4692 single nucleotide polymorphism (SNPs). We identified a SNP within a putative transcription factor binding site in the NEDD9 gene (neural precursor cell expressed, developmentally down-regulated), that shows good evidence of association with disease risk in four out of five LOAD samples [N = 3521, P = 5.38×10-6, odds ratio (OR) = 1.38 (1.20-1.59)] and in addition, we observed a similar pattern of association in two PD sample sets [N = 1464, P = 0.0145, OR = 1.31 (1.05-1.62)]. In exploring a potential mechanism for the association, we observed that expression of NEDD9 and APOE show a strong inverse correlation in the hippocampus of Alzheimer's cases. These data implicate NEDD9 as a novel susceptibility gene for LOAD and possibly PD. © The Author 2007. Published by Oxford University Press. All rights reserved.
Authors & Co-Authors
Holmans, Peter A.
United Kingdom, Cardiff
Cardiff University
Segurado, Ricardo
United Kingdom, Cardiff
Cardiff University
Jones, Lesley
United Kingdom, Cardiff
Cardiff University
Cairns, Nigel J.
United States, St. Louis
Washington University School of Medicine in St. Louis
Racette, Brad A.
United States, St. Louis
Washington University School of Medicine in St. Louis
Perlmutter, Joel S.
United States, St. Louis
Washington University School of Medicine in St. Louis
O'Donovan, Michael Conlon
United Kingdom, Cardiff
Cardiff University
Morris, John Carl
United States, St. Louis
Washington University School of Medicine in St. Louis
Brayne, C. E.G.
United Kingdom, Cambridge
University of Cambridge
Rubinsztein, David Chaim
United Kingdom, Cambridge
University of Cambridge
Lovestone, Simon
United Kingdom, London
King's College London
Owen, Michael John
United Kingdom, Cardiff
Cardiff University
Statistics
Citations: 47
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1093/hmg/ddm348
ISSN:
14602083
Research Areas
Genetics And Genomics
Study Design
Case-Control Study