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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group
Biological Psychiatry, Volume 92, No. 9, Year 2022
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Description
Background: The pattern of structural brain abnormalities in anorexia nervosa (AN) is still not well understood. While several studies report substantial deficits in gray matter volume and cortical thickness in acutely underweight patients, others find no differences, or even increases in patients compared with healthy control subjects. Recent weight regain before scanning may explain some of this heterogeneity. To clarify the extent, magnitude, and dependencies of gray matter changes in AN, we conducted a prospective, coordinated meta-analysis of multicenter neuroimaging data. Methods: We analyzed T1-weighted structural magnetic resonance imaging scans assessed with standardized methods from 685 female patients with AN and 963 female healthy control subjects across 22 sites worldwide. In addition to a case-control comparison, we conducted a 3-group analysis comparing healthy control subjects with acutely underweight AN patients (n = 466) and partially weight-restored patients in treatment (n = 251). Results: In AN, reductions in cortical thickness, subcortical volumes, and, to a lesser extent, cortical surface area were sizable (Cohen's d up to 0.95), widespread, and colocalized with hub regions. Highlighting the effects of undernutrition, these deficits were associated with lower body mass index in the AN sample and were less pronounced in partially weight-restored patients. Conclusions: The effect sizes observed for cortical thickness deficits in acute AN are the largest of any psychiatric disorder investigated in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium to date. These results confirm the importance of considering weight loss and renutrition in biomedical research on AN and underscore the importance of treatment engagement to prevent potentially long-lasting structural brain changes in this population. © 2022 Society of Biological Psychiatry
Authors & Co-Authors
Walton, Esther
United Kingdom, Bath
University of Bath
Bernardoni, Fabio
Germany, Dresden
Technische Universität Dresden
Larivière, Sara
Canada, Montreal
Université Mcgill
Bischoff-Grethe, Amanda
United States, La Jolla
University of California, San Diego
Brooks, Samantha Jane
United Kingdom, Liverpool
Liverpool John Moores University
Sweden, Uppsala
Uppsala Universitet
Danner, Unna Nora
Netherlands, Utrecht
Universiteit Utrecht
Favaro, Angela
Italy, Padua
Università Degli Studi Di Padova
Feusner, Jamie Donald
Canada, Toronto
Centre for Addiction and Mental Health
United States, Los Angeles
University of California, Los Angeles
Friederich, Hans Christoph
Germany, Heidelberg
Universitätsklinikum Heidelberg
Heß, Andreas
Germany, Erlangen
Friedrich-alexander-universität Erlangen-nürnberg
Kaplan, Allan S.
Canada, Toronto
Centre for Addiction and Mental Health
Kaye, Walter H.
United States, La Jolla
University of California, San Diego
LaBar, Kevin S.
United States, Durham
Duke University
Lázaro, María Luisa
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Monteleone, Alessio Maria
Italy, Naples
Università Degli Studi Della Campania Luigi Vanvitelli
Monteleone, Palmiero
Italy, Salerno
Università Degli Studi Di Salerno
Pariente, Jose C.
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Tamnes, Christian Krog
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Diakonhjemmet Sykehus
Thomopoulos, Sophia I.
United States, Los Angeles
University of Southern California
Voineskos, Aristotle N.
Canada, Toronto
Centre for Addiction and Mental Health
Canada, Toronto
University of Toronto
Jahanshad, Neda
United States, Los Angeles
University of Southern California
King, Joseph A.
Germany, Dresden
Technische Universität Dresden
Thompson, Paul M.
United States, Los Angeles
University of Southern California
Ehrlich, Stefan
Germany, Dresden
Technische Universität Dresden
Statistics
Citations: 21
Authors: 24
Affiliations: 35
Identifiers
Doi:
10.1016/j.biopsych.2022.04.022
ISSN:
00063223
Research Areas
Food Security
Genetics And Genomics
Mental Health
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Approach
Systematic review
Participants Gender
Female