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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Evolutionary origins, diversification, and biogeography of liver flukes (Digenea, Fasciolidae)
American Journal of Tropical Medicine and Hygiene, Volume 79, No. 2, Year 2008
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Description
Fasciolid flukes are among the largest and best known digenetic trematodes and have considerable historical and veterinary significance. Fasciola hepatica is commonly implicated in causing disease in humans. The origins, patterns of diversification, and biogeography of fasciolids are all poorly known. We have undertaken a molecular phylogenetic study using 28S, internal transcribed spacer 1 and 2 (ITS-1 and ITS-2) of nuclear ribosomal DNA, and mitochondrial nicotinamide dehydrogenase subunit 1 (nad1) that included seven of the nine recognized species in the family. The fasciolids examined comprise a monophyletic group with the most basal species recovered from African elephants. We hypothesize fasciolids migrated from Africa to Eurasia, with secondary colonization of Africa. Fasciolids have been conservative in maintaining relatively large adult body size, but anatomical features of their digestive and reproductive systems are available. These flukes have been opportunistic, with respect to switching to new snail (plan-orbid to lymnaeid) and mammalian hosts and from intestinal to hepatic habitats within mammals. Copyright © 2008 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Lotfy, Wael Mohamed
Egypt, Alexandria
Alexandria University
Brant, Sara Vanessa
United States, Albuquerque
The University of new Mexico
DeJong, Randall J.
United States, Grand Rapids
Calvin University
Thanh, Hoa Le
Viet Nam, Hanoi
Institute of Biotechnology
Demiaszkiewicz, Aleksander
Poland, Warsaw
Witold Stefański Institute of Parasitology of the Polish Academy of Sciences
Rajapakse, R. P.V.Jayanthe
Sri Lanka, Peradeniya
University of Peradeniya
Perera, Vijitha B.V.P.
Sri Lanka
National Wildlife Training Center
Laursen, Jeff R.
United States, Charleston
Eastern Illinois University
Loker, Eric Samuel
United States, Albuquerque
The University of new Mexico
Statistics
Citations: 110
Authors: 9
Affiliations: 8
Identifiers
Doi:
10.4269/ajtmh.2008.79.248
ISSN:
00029637
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Sexual And Reproductive Health