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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Identification of HIV type 1 group N infections in a husband and wife in Cameroon: Viral genome sequences provide evidence for horizontal transmission
AIDS Research and Human Retroviruses, Volume 22, No. 1, Year 2006
Notification
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Description
HIV-1 is classified into three groups, M (major), N (non-M non-O), and O (outlier); each group arose from a separate transmission of SIVcpz into humans. HIV-1 group N was recently discovered and infections with this virus are rare with only eight documented cases. All group N infections have been found in Cameroon and there is no evidence of direct linkage between the infected patients. We report here the identification of HIV-1 group N infections in a husband and wife. The group N infection in the husband, 1131-03, was identified first based on seroreactivity in peptide EIAs and confirmed by PCR amplification of group N viral sequences. Subsequently the wife, 1015-04, was evaluated and confirmed to also be infected with a group N virus. Near full-length viral genomes were amplified and sequenced from each patient's specimen. The low level of diversity between the two viral sequences provides evidence of horizontal transmission of group N from one spouse to the other. Patient 1131-03 was receiving antiviral therapy consisting of reverse transcriptase inhibitors; the treatment appears effective for suppression of group N viral replication based on apparently low viral load in plasma specimens collected from the patient and the absence of drug resistance mutations in RT sequences amplified from 1131-03. This report brings to 10 the number of group N infections identified and to 5 the number of group N genomes sequenced. Although group N infections continue to be rare, group N is a pathogenic virus and its prevalence needs to be monitored. © Mary Ann Liebert, Inc.
Authors & Co-Authors
Yamaguchi, Julie
United States, Chicago
Abbott Laboratories
Coffey, Ruthie
United States, Chicago
Abbott Laboratories
Vallari, Ana S.
United States, Chicago
Abbott Laboratories
Ngansop, Charlotte
Cameroon, Yaounde
Université de Yaoundé I
Mbanya, Dora Ngum Shu
Cameroon, Yaounde
Université de Yaoundé I
Ndembi, Nicaise N.
Cameroon, Yaounde
Université de Yaoundé I
Kaptué, Lazare Noche
Cameroon, Yaounde
Université de Yaoundé I
Gürtler, Lutz G. G.
Germany, Greifswald
Universität Greifswald
Bodelle, Pierre
United States, Chicago
Abbott Laboratories
Schochetman, Gerald C.
United States, Chicago
Abbott Laboratories
Devare, Sushil G.
United States, Chicago
Abbott Laboratories
Brennan, Catherine A.
United States, Chicago
Abbott Laboratories
Statistics
Citations: 53
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1089/aid.2006.22.83
ISSN:
08892229
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Cameroon