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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Efficacy of a foodlet-based multiple micronutrient supplement for preventing growth faltering, anemia, and micronutrient deficiency of infants: The four country IRIS trial pooled data analysis
Journal of Nutrition, Volume 135, No. 3, Year 2005
Notification
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Description
Diets of infants across the world are commonly deficient in multiple micronutrients during the period of growth faltering and dietary transition from milk to solid foods. A randomized placebo controlled trial was carried out in Indonesia, Peru, South Africa, and Vietnam, using a common protocol to investigate whether improving status for multiple micronutrients prevented growth faltering and anemia during infancy. The results of the pooled data analysis of the 4 countries for growth, anemia, and micronutrient status are reported. A total of 1134 infants were randomized to 4 treatment groups, with 283 receiving a daily placebo (P), 283 receiving a weekly multiple micronutrient supplement (WMM), 280 received a daily multiple micronutrient (DMM) supplement, and 288 received daily iron (DI) supplements. The DMM group had a significantly greater weight gain, growing at an average rate of 207 g/mo compared with 192 g/mo for the WMM group, and 186 g/mo for the DI and P groups. There were no differences in height gain. DMM was also the most effective treatment for controlling anemia and iron deficiency, besides improving zinc, retinol, tocopherol, and riboflavin status. DI supplementation alone increased zinc deficiency. The prevalence of multiple micronutrient deficiencies at baseline was high, with anemia affecting the majority, and was not fully controlled even after 6 mo of supplementation. These positive results indicate the need for larger effectiveness trials to examine how to deliver supplements at the program scale and to estimate cost benefits. Consideration should also be given to increasing the dosages of micronutrients being delivered in the foodlets. © 2005 American Society for Nutritional Sciences.
Authors & Co-Authors
Smuts, Cornelius Marius
South Africa, Tygerberg
South African Medical Research Council
Lombard, Carl J.
South Africa, Tygerberg
South African Medical Research Council
Spinnler Benadé, Ambrose J.
South Africa, Tygerberg
South African Medical Research Council
Dhansay, M. A.
South Africa, Tygerberg
South African Medical Research Council
Berger, Jacques
Viet Nam, Hanoi
Center for Sustainable Development Studies
Hop, Lethi
Viet Nam, Hanoi
National Institute of Nutrition Vietnam
López De Romaña, Guillermo
Peru, Lima
Universidad Nacional Agraria la Molina
Untoro, Juliawati
Indonesia, Depok
Universitas Indonesia
Karyadi, Elvina
Indonesia, Depok
Universitas Indonesia
Erhardt, Juergen Georg
Germany, Stuttgart
Universität Hohenheim
Groß, Rainer
United States, New York
Unicef
Statistics
Citations: 95
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1093/jn/135.3.631s
ISSN:
00223166
Study Design
Cross Sectional Study
Study Locations
South Africa