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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Dibenzofurans from the marine sponge-derived ascomycete Super1F1-09
Botanica Marina, Volume 53, No. 6, Year 2010
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Description
Three dibenzofurans hitherto undescribed from nature and one known butyrolactone were isolated from the extract of the ascomycete Super1F1-09 isolated from the Fijian marine sponge Acanthella cavernosa. The isolated compounds were identified as 3,9-dimethyldibenzo[b,d]furan-1,7-diol (1), 3-(hydroxymethyl)-9-methyldibenzo[b,d]furan-1,7-diol (2), 1,7-dihydroxy-9- methyldibenzo[b,d]furan-3-carboxylic acid (3), and the known butyrolactone I (4) using different NMR spectroscopic techniques and accurate mass spectrometric analysis. 1 was synthesized together with structurally related dibenzofurans 6-8. 1 and 4 had moderate antibacterial activity toward Mycobacterium marinum and Staphylococcus aureus, whereas 2 and 3 proved inactive. In addition, all compounds had moderate inhibitory properties against epidermal growth factor receptor tyrosine kinase. © 2010 by Walter de Gruyter Berlin New York 2010.
Authors & Co-Authors
Rateb, Mostafa Ezzat M.
United Kingdom, Aberdeen
University of Aberdeen
Egypt, Beni Suef
Faculty of Pharmacy
Houssen, Wael E.
United Kingdom, Aberdeen
University of Aberdeen
Legrave, Nathalie M.
France, Aubiere
Ecole Nationale Supérieure de Chimie de Clermont-ferrand
Clements, Carol Jean
United Kingdom, Glasgow
University of Strathclyde
Jaspars, Marcel
United Kingdom, Aberdeen
University of Aberdeen
Ebel, Rainer
United Kingdom, Aberdeen
University of Aberdeen
Statistics
Citations: 19
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1515/BOT.2010.064
ISSN:
00068055
e-ISSN:
14374323