Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge
Vaccine, Volume 23, No. 23, Year 2005
Notification
URL copied to clipboard!
Description
Two recombinant vaccines against Theileria parva, based on a near full-length version of the sporozoite surface antigen p67 (p67635), or an 80 amino acid C-terminal section (p67C), were evaluated by exposure of immunized cattle to natural tick challenge in two sites at the Kenya Coast and one in Central Kenya. Vaccination reduced severe ECF by 47% at the coast and by 52% in central Kenya from an average incidence of 0.53 ± 0.07 (S.E.) in 50 non-immunised controls to an average of 0.27 ± 0.05 in 83 immunised animals. The reduction in severe East Coast fever was similar to that observed in laboratory experiments with p67635 and p67C. The p67 coding sequence from thirteen T. parva field isolates including seven from vaccinated cattle that were not protected, was 100% identical to the gene on which the recombinant vaccine is based, suggesting a predominantly homologous p67 antigenic challenge. The same parasite isolates were however genetically heterogeneous at several loci other than p67. © 2004 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Musoke, Anthony Jim Tony
Kenya, Nairobi
International Livestock Research Institute Nairobi
Rowlands, John
Kenya, Nairobi
International Livestock Research Institute Nairobi
Nene, Vishvanath M.
Kenya, Nairobi
International Livestock Research Institute Nairobi
United States, Rockville
J. Craig Venter Institute
Nyanjui, John K.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Katende, Joseph M.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Spooner, Paul R.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Mwaura, Stephen N.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Odongo, David Otieno
Kenya, Nairobi
International Livestock Research Institute Nairobi
Nkonge, C. G.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Mbogo, Samuel Kamau
Kenya, Nairobi
International Livestock Research Institute Nairobi
Kenya, Nairobi
Kenya Agricultural Research Institute
Bishop, Richard Peter
Kenya, Nairobi
International Livestock Research Institute Nairobi
Morzaria, Subhash P.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Thailand, Bangkok
Fao Regional Office for Asia and the Pacific
Statistics
Citations: 63
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1016/j.vaccine.2004.09.039
ISSN:
0264410X
Research Areas
Genetics And Genomics
Study Design
Cohort Study
Study Locations
Kenya