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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Lipoproteins as mediators for the effects of alcohol consumption and cigarette smoking on cardiovascular mortality: Results from the lipid research clinics follow-up study
American Journal of Epidemiology, Volume 126, No. 4, Year 1987
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Description
Criqui, M. H. (Dept of Community and Family Medicine, U. of California, San Diego, La Jolla, CA 92093), L. D. Cowan, H. A. Tyroler, S. Bangdiwala, Q. Heiss, R. B. Wallace, and R. Conn. Upoproteins as mediators for the effects of alcohol consumption and cigarette smoking on cardiovascular mortality: results from the Upid Research Clinics Follow-up Study. Am J Epidemiol 1987; 126:629-37.Because alcohol consumption is associated with increased high density lipoprotein (HDL) cholesterol and decreased low density lipoprotein (LDL) cholesterol, and cigarette smoking is associated with lower HDL cholesterol and higher LDL cholesterol, there has been speculation that the protective effect of moderate alcohol consumption and/or the noxious effect of cigarette smoking for cardiovascular disease might be mediated in large part by a lipoprotein mechanism. The authors examined this question in a prospective study of 7,481 men and women in 10 North American populations initially seen in 1972-1976 and followed for an average of 8.5 years. Moderate alcohol consumption was weakly protective for cardiovascular disease, while cigarette smoking was strongly and significantly associated with cardiovascular disease mortality. As expected, LDL cholesterol was positively related and HDL cholesterol was inversely related to cardiovascular disease mortalIty. However, multivarlable analysis of cardiovascular disease mortality alternately excluding and including HDL cholesterol and LDL cholesterol as covariates indicated that the effect of alcohol consumption on cardiovascular disease mortality was independent of an LDL cholesterol pathway and only partially mediated by an HDL cholesterol pathway, while the effect of cigarette smoking was independent of both the HDL cholesterol and LDL cholesterol pathways, suggesting alternative biologic mechanisms of action for both alcohol consumption and cigarette smoking on cardiovascular disease. © 1987 by The Johns Hopkins University School of Hygiene and Public Health.
Authors & Co-Authors
Criqui, Michael H.
United States, La Jolla
University of California, San Diego
Cowan, Linda Demetry
United States, Norman
The University of Oklahoma
Bangdiwala, Shrikant I.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Heiss, Gerardo M.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Wallace, Robert Bruce
United States, Iowa City
University of Iowa Hospitals & Clinics
Statistics
Citations: 254
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1093/oxfordjournals.aje.a114702
ISSN:
00029262
Research Areas
Health System And Policy
Noncommunicable Diseases
Substance Abuse
Study Design
Cohort Study
Participants Gender
Male
Female