Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Anti-tuberculosis therapy-induced hepatotoxicity among Ethiopian HIV-positive and negative patients
PLoS ONE, Volume 3, No. 3, Article e1809, Year 2008
Notification
URL copied to clipboard!
Description
Background: To assess and compare the prevalence, severity and prognosis of anti-TB drug induced hepatotoxicity (DIH) in HIV positive and HIV negative tuberculosis (TB) patients in Ethiopia. Methodology/Principal Findings: In this study, 103 HIV positive and 94 HIV negative TB patients were enrolled. All patients were evaluated for different risk factors and monitored biochemically and clinically for development of DIH. Sub-clinical hepatotoxicity was observed in 17.3% of the patients and 8 out of the 197 (4.1%) developed clinical hepatoxicity. Seven of the 8 were HIV positive and 2 were positive for HBsAg. Conclusions/Significance: Sub-clinical hepatotoxicity was significantly associated with HIV co-infection (p=0.002), concomittant drug intake (p=0.008), and decrease in CD4 count (p=0.001). Stepwise restarting of anti TB treatment was also succesful in almost all the patients who developed clinical DIH. We therefore conclude that anti-TB DIH is a major problem in HIV-associated TB with a decline in immune status and that there is a need for a regular biochemical and clinical follow up for those patients who are at risk. © 2008 Yimer et al.
Authors & Co-Authors
Yimer, Getnet
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Ethiopia, Addis Ababa
School of Medicine
Aderaye, Getachew
Ethiopia, Addis Ababa
School of Medicine
Amogne, Wondwossen
Ethiopia, Addis Ababa
School of Medicine
Makonnen, Eyasu
Ethiopia, Addis Ababa
School of Medicine
Aklillu, Eleni
Sweden, Stockholm
Karolinska Institutet
Lindquist, Lars
Sweden, Stockholm
Karolinska Institutet
Yamuah, Lawrence K.
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Feleke, Beniam
Ethiopia, Addis Ababa
St. Peter Specialized Hospital
Aseffa, Abraham
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Statistics
Citations: 75
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0001809
e-ISSN:
19326203
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Ethiopia