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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Actinomycetes from red sea sponges: Sources for chemical and phylogenetic diversity
Marine Drugs, Volume 12, No. 5, Year 2014
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Description
The diversity of actinomycetes associated with marine sponges collected off Fsar Reef (Saudi Arabia) was investigated in the present study. Forty-seven actinomycetes were cultivated and phylogenetically identified based on 16S rRNA gene sequencing and were assigned to 10 different actinomycete genera. Eight putatively novel species belonging to genera Kocuria, Mycobacterium, Nocardia, and Rhodococcus were identified based on sequence similarity values below 98.2% to other 16S rRNA gene sequences available in the NCBI database. PCR-based screening for biosynthetic genes including type I and type II polyketide synthases (PKS-I, PKS-II) as well as nonribosomal peptide synthetases (NRPS) showed that 20 actinomycete isolates encoded each at least one type of biosynthetic gene. The organic extracts of nine isolates displayed bioactivity against at least one of the test pathogens, which were Gram-positive and Gram-negative bacteria, fungi, human parasites, as well as in a West Nile Virus protease enzymatic assay. These results emphasize that marine sponges are a prolific resource for novel bioactive actinomycetes with potential for drug discovery. © 2014 by the authors; licensee MDPI.
Authors & Co-Authors
Abdelmohsen, Usama Ramadan
Germany, Wurzburg
Biozentrum Der Universität Würzburg
Egypt, Minya
Faculty of Pharmacy
Yang, Chen
Saudi Arabia, Thuwal
King Abdullah University of Science and Technology
Horn, Hannes
Germany, Wurzburg
Biozentrum Der Universität Würzburg
Hajjar, Dina
Saudi Arabia, Thuwal
King Abdullah University of Science and Technology
Ravasi, Timothy
Saudi Arabia, Thuwal
King Abdullah University of Science and Technology
Hentschel, Ute
Germany, Wurzburg
Biozentrum Der Universität Würzburg
Statistics
Citations: 73
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.3390/md12052771
e-ISSN:
16603397
Research Areas
Genetics And Genomics