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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Risk factors for high-risk human papillomavirus infection in unscreened Malian women
Tropical Medicine and International Health, Volume 16, No. 11, Year 2011
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Description
Objective To investigate the epidemiology of human papillomavirus (HPV) infection in Malian women, for whom cervical cancer is the most common cancer and the second most common cause of cancer-related mortality. Methods Pilot study of 202 women aged 15-65 to determine the prevalence rate of high-risk HPV infection among unscreened Malian women. Information on risk factors was collected through a standardized, structured interview and clinical examination. High-risk (HR) HPV DNA was detected using signal amplification methods (hybrid capture II). Results High-risk HPV DNA was detected in 12% of unscreened women, while visual inspection after application of acetic acid and Lugol's iodine (VIA/VILI) identified suspicious abnormalities in 2.5% of unscreened women. Histopathological evaluation of VIA/VILI-positive biopsies revealed no evidence of cervical intraepithelial neoplasia or cervical cancer. The majority of infections occurred among women in the 15-24year old range. Compared to women who were married or widowed, single women were 3.5 times more likely to be infected with HR HPV. Conclusions The prevalence of infection with cancer causing types of HPV in this study was 12%. These prevalence estimates are consistent with what has been reported previously for other West African countries. © 2011 Blackwell Publishing Ltd.
Authors & Co-Authors
Tracy, J. Kathleen
United States, Baltimore
University of Maryland School of Medicine
Traoré, Cheick Bougadari
Mali, Bamako
Institut National de Recherche en Sante Publique Mali
Bakarou, Kamate
Mali, Bamako
Institut National de Recherche en Sante Publique Mali
Dembélé, Rokiatou D.
Mali, Bamako
Centre Pour le Développement Des Vaccins
Coulibaly, Rokiatou C.
Mali, Bamako
Institut National de Recherche en Sante Publique Mali
Mali, Bamako
Centre Pour le Développement Des Vaccins
Sow, Samba Ousmane
Mali, Bamako
Centre Pour le Développement Des Vaccins
United States, Baltimore
University of Maryland School of Medicine
Statistics
Citations: 14
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1111/j.1365-3156.2011.02843.x
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Participants Gender
Female