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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Eosinopenia, an early marker of increased mortality in critically ill medical patients
Intensive Care Medicine, Volume 37, No. 7, Year 2011
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Description
Purpose: Inflammatory markers may have a role in predicting severity of illness of intensive care unit (ICU) patients. The aim of this study is to determine whether low eosinophil count can predict 28-day mortality in medical ICU. Methods: A prospective study over a 4-month period. To evaluate the prognosis information provided by eosinophil count, we compared the variations in eosinophil count from ICU admission to seventh day between patients who survived and those who died. The best cutoff value was chosen using Younden's index for identification of patients with high risk of mortality. The patient outcome was 28-day mortality. Results: A total of 200 patients were eligible. Overall 28-day ICU mortality was 28% (n = 56). At ICU admission, the median eosinophil count was significantly different in survivors [30 cells/mm3; interquartile range (IQR), 0-100 cells/mm3] and nonsurvivors (0 cells/mm3; IQR, 0-30 cells/mm3; P = 0.004). Absolute eosinophil counts remained significantly lower in nonsurvivors from admission to seventh day. The 28-day mortality was significantly higher in patients with eosinopenia <40 cells/mm 3 (P = 0.011). Multivariate analysis by Cox model with time-dependent covariates demonstrated that eosinophil count <40 cells/mm 3 [hazard ratio (HR), 1.85; 95% confidence interval (CI), 1.01-3.42; P = 0.046], high Acute Physiology and Chronic Health Evaluation (APACHE) II score (HR, 1.08; 95% CI, 1.01-1.14; P = 0.014), high Sequential Organ Failure Assessment (SOFA) score (HR, 1.14; 95% CI, 1.03-1.25; P = 0.008), and use of mechanical ventilation (HR, 27.48; 95% CI, 12.12-62.28; P < 0.001) were independent predictors of 28-day all-cause mortality. Conclusion: This study suggests the possibility to use eosinophil cell count at admission and during the first 7 days as a prognosis marker of mortality in medical ICU. © 2011 Copyright jointly held by Springer and ESICM.
Authors & Co-Authors
Abidi, Khalid
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Belayachi, Jihane
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Derras, Youssef
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Khayari, Mina El
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Dendane, Tarek
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Madani, Naoufel N.
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Khoudri, Ibtissam
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Zeggwagh, Amine Ali
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Morocco, Rabat
Mohammed V University in Rabat
Abouqal, Redouane
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Morocco, Rabat
Mohammed V University in Rabat
Statistics
Citations: 92
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1007/s00134-011-2170-z
ISSN:
03424642
e-ISSN:
14321238
Research Areas
Environmental
Health System And Policy
Study Design
Cohort Study