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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism
Journal of the American College of Cardiology, Volume 60, No. 8, Year 2012
Notification
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Description
The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components. It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coronary artery disease (CAD), confer susceptibility predominantly via atherosclerosis or thrombosis. The 2 LPA variants were combined and examined as LPA scores for the association with ischemic stroke (and TOAST [Trial of Org 10172 in Acute Stroke Treatment] subtypes) (effective sample size [n e] = 9,396); peripheral arterial disease (n e = 5,215); abdominal aortic aneurysm (n e = 4,572); venous thromboembolism (n e = 4,607); intracranial aneurysm (n e = 1,328); CAD (n e = 12,716), carotid intima-media thickness (n = 3,714), and angiographic CAD severity (n = 5,588). LPA score was associated with ischemic stroke subtype large artery atherosclerosis (odds ratio [OR]: 1.27; p = 6.7 × 10 4), peripheral artery disease (OR: 1.47; p = 2.9 × 10 14), and abdominal aortic aneurysm (OR: 1.23; p = 6.0 × 10 5), but not with the ischemic stroke subtypes cardioembolism (OR: 1.03; p = 0.69) or small vessel disease (OR: 1.06; p = 0.52). Although the LPA variants were not associated with carotid intima-media thickness, they were associated with the number of obstructed coronary vessels (p = 4.8 × 10 12). Furthermore, CAD cases carrying LPA risk variants had increased susceptibility to atherosclerotic manifestations outside of the coronary tree (OR: 1.26; p = 0.0010) and had earlier onset of CAD (1.58 years/allele; p = 8.2 × 10 8) than CAD cases not carrying the risk variants. There was no association of LPA score with venous thromboembolism (OR: 0.97; p = 0.63) or intracranial aneurysm (OR: 0.85; p = 0.15). LPA sequence variants were associated with atherosclerotic burden, but not with primarily thrombotic phenotypes. © 2012 American College of Cardiology Foundation.
Authors & Co-Authors
Helgadóttir, Anna
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Grétarsdóttir, Sólveig
Iceland, Reykjavik
Decode Genetics
Thorleifsson, Gudmar
Iceland, Reykjavik
Decode Genetics
Hólm, Hilma
Iceland, Reykjavik
Decode Genetics
Patel, Riyaz S.
United States, Atlanta
Emory University School of Medicine
United Kingdom, Cardiff
Cardiff University
Gudnason, Thórarinn
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Jones, Gregory Thomas
New Zealand, Dunedin
Otago Medical School
van Rij, Andrè M.
New Zealand, Dunedin
Otago Medical School
Eapen, Danny J.
United States, Atlanta
Emory University School of Medicine
Baas, Annette F.
Netherlands, Utrecht
University Medical Center Utrecht
Trégouët, David Alexandre
France, Paris
Inserm
Morange, Pierre Emmanuel
France, Paris
Inserm
Emmerich, Joseph D.
France, Paris
Inserm
Lindblad, Bengt L.T.
Sweden, Lund
Skånes Universitetssjukhus
Gottster, Anders
Sweden, Lund
Skånes Universitetssjukhus
Kiemeny, Lambertus A.
Netherlands, Nijmegen
Radboud University Medical Center
Lindholt, J. Sanddal
Denmark, Viborg
Regionshospitalet Viborg
Sakalihasan, Natzi
Belgium, Liege
Centre Hospitalier Universitaire de Liege
Ferrell, Robert E.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Carey, David J.
United States, Danville
Weis Center for Research
Elmore, James R.
United States, Danville
Geisinger Medical Center
Tsao, Phillip Shih Chung
United States, Stanford
Stanford University School of Medicine
Grarup, Niels
Denmark, Copenhagen
Novo Nordisk Foundation Center for Basic Metabolic Research
Jörgensen, Torben J.
Denmark, Glostrup
Amtssygehuset I Glostrup
Denmark, Copenhagen
Det Sundhedsvidenskabelige Fakultet
Witte, Daniel R.
Denmark, Herlev
Steno Diabetes Center Copenhagen
Hansen, Torben Frøstrup
Denmark, Copenhagen
Novo Nordisk Foundation Center for Basic Metabolic Research
Denmark, Odense
Syddansk Universitet
Pedersen, Oluf Borbye
Denmark, Copenhagen
Novo Nordisk Foundation Center for Basic Metabolic Research
Denmark, Gentofte
Hagedorn Research Institute
Denmark, Copenhagen
Det Sundhedsvidenskabelige Fakultet
Denmark, Aarhus
Fakultetet Health
Pola, Roberto
Italy, Rome
Fondazione Policlinico Universitario Agostino Gemelli Irccs
United States, Boston
Tufts University School of Medicine
Gaetani, Eleonora
Italy, Rome
Fondazione Policlinico Universitario Agostino Gemelli Irccs
Magnadóttir, Hulda Bra
United States, Lebanon
Upper Valley Neurology Neurosurgery
Wijmenga, Cisca
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Tromp, Gerard C.
United States, Danville
Weis Center for Research
Ronkainen, Antti
Finland, Kuopio
Kuopio University Hospital
Ruigrok, Ynte Marije
Netherlands, Utrecht
Rudolf Magnus Institute of Neuroscience
Blankensteijn, J. D.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Netherlands, Nijmegen
Radboud University Medical Center
Mueller, Thomas J.
Austria, Vienna
Medizinische Universität Wien
Wells, Philip Stephen
Canada, Ottawa
Ottawa Hospital Research Institute
Corral, Javier M.
Spain, Murcia
Universidad de Murcia
Soria, Jose Manuel
Spain, Barcelona
Hospital de la Santa Creu I Sant Pau
Souto, Juan Carlos
Spain, Barcelona
Hospital de la Santa Creu I Sant Pau
Peden, John F.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Jalilzadeh, Shapour
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Mayosi, Bongani M.
South Africa, Cape Town
Faculty of Health Sciences
Keavney, Bernard D.
United Kingdom, Newcastle
University of Newcastle Upon Tyne, Faculty of Medical Sciences
Strawbridge, Rona J.
Sweden, Stockholm
Karolinska Institutet
Sabater-Lleal, Maria
Sweden, Stockholm
Karolinska Institutet
Gertow, Karl
Sweden, Stockholm
Karolinska Institutet
Baldassarre, D.
Italy, Milan
Università Degli Studi Di Milano
Nyyssnen, Kristiina
Finland, Kuopio
Itä-suomen Yliopisto
Rauramaa, Rainer
Finland, Kuopio
Itä-suomen Yliopisto
Smit, Andries J.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Mannarino, Elmo
Italy, Perugia
Università Degli Studi Di Perugia
Giral, Philippe
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Tremoli, Elena
Italy, Milan
Università Degli Studi Di Milano
Dé Fairé, Ulf H.
Sweden, Stockholm
Karolinska Institutet
Humphries, Steve Eric
United Kingdom, London
University College London
Hamsten, Anders
Sweden, Stockholm
Karolinska Institutet
Haraldsdóttir, Vilhelmína
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Ólafsson, Ísleifur
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Magnússon, Magnús Karl
Iceland, Reykjavik
Haskoli Islands
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Samani, Nilesh J.
United Kingdom, Leicester
University of Leicester
United Kingdom, London
Nihr Biomedical Research Unit for Dementia
Levey, Aĺlan I.
United States, Atlanta
Emory University School of Medicine
Markus, Hugh Stephen
United Kingdom, London
St George’s, University of London
Kostulas, Konstantinos
Sweden, Stockholm
Karolinska Universitetssjukhuset
Dichgans, Martin
Germany, Munich
Klinikum Der Universität München
Berger, Klaus Ulrich
Germany, Munster
University of Münster
Kuhlenbumer, Gregor
Germany, Kiel
Christian-albrechts-universität zu Kiel
Ringelstein, E. Bernd
Germany, Munster
University of Münster
Stoll, Monika
Germany, Munster
University of Münster
Seedorf, Udo
Germany, Munster
University of Münster
Rothwell, Peter M.
United Kingdom, Oxford
John Radcliffe Hospital
Powell, Janet Tinka
United Kingdom, London
Imperial College London
Kuivaniemi, Helena
United States, Danville
Weis Center for Research
Onundarson, Pall T.
Iceland, Reykjavik
Haskoli Islands
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Valdimarsson, Einar Már
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Matthíasson, Stefán E.
Iceland, Reykjavik
Laekning
Gudbjartsson, Daníel Fannar
Iceland, Reykjavik
Decode Genetics
Thorgeirsson, Gudmundur
Iceland, Reykjavik
Haskoli Islands
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Erdmann, Jeanette Ali
United States, Atlanta
Emory University School of Medicine
Watkins, Hugh C.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Farrall, Martin
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Thorsteinsdottir, Unnur Arna
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Stefánsson, Kári
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Statistics
Citations: 168
Authors: 83
Affiliations: 53
Identifiers
Doi:
10.1016/j.jacc.2012.01.078
ISSN:
07351097
e-ISSN:
15583597
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Case-Control Study