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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Brain atrophy associations with white matter lesions in the ageing brain: The Lothian Birth Cohort 1936
European Radiology, Volume 23, No. 4, Year 2013
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Description
Objective: Cerebral atrophy and white matter lesions (WMLs) are common in older people with common risk factors, but it is unclear if they are related. We investigated whether and to what degree they are related in deep and superficial structures using both volumetric and visual ratings. Methods: The intracranial, total brain tissue (TBV), cerebrospinal fluid (CSF), ventricular superficial subarachnoid space (SSS), grey matter, normal-appearing white matter, WMLs, and combined CSF, venous sinuses and dural volumes were measured. WMLs were also rated using the Fazekas scale. Results: Amongst 672 adults (mean age 73 ± 1 years), WMLs were associated with global brain atrophy (TBV, β = -0.43 mm3, P < 0.01) and specifically with deep (ventricular enlargement, β = 0.10 mm3, P = 0.03) rather than superficial (SSS, β = 0.09 mm3, P = 0.55) atrophy. A 1 mm 3 increase in WML volume was associated with a 0.43 mm3 decrease in TBV and 0.10 mm3 increase in ventricular volume. WMLs were associated with combined CSF + Venous Sinuses + Meninges volumes, but not CSF volume alone. Some of the associations were attenuated after correcting for vascular risk factors. The associations were similar for visually scored WMLs. Conclusion: WMLs are associated with brain atrophy, primarily with deep brain structures. Measures of brain atrophy should include all intracranial structures when assessing brain shrinkage. Key Points: • Increasing age-related white matter lesions (WML) are modestly associated with brain atrophy. • Most associated atrophy affects deep structures (white matter, basal ganglia, etc.). • This is true whether WMLs are assessed volumetrically or visually scored. • Precise evaluation of brain atrophy requires assessment of all intracranial tissues. © 2012 European Society of Radiology.
Authors & Co-Authors
Aribisala, Benjamin Segun
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
A Platform for Scientific Excellence Sinapse Collaboration
United Kingdom, Edinburgh
Western General Hospital
Valdés-Hernández, Maria Del Carmen
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
A Platform for Scientific Excellence Sinapse Collaboration
Royle, Natalie A.
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
A Platform for Scientific Excellence Sinapse Collaboration
Morris, Zoe
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
A Platform for Scientific Excellence Sinapse Collaboration
Muñoz Maniega, Susana
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
A Platform for Scientific Excellence Sinapse Collaboration
Bastin, Mark E.
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
A Platform for Scientific Excellence Sinapse Collaboration
Deary, Ian J.
United Kingdom, Edinburgh
The University of Edinburgh
Wardlaw, Joanna M.
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
A Platform for Scientific Excellence Sinapse Collaboration
Statistics
Citations: 82
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1007/s00330-012-2677-x
ISSN:
09387994
Study Design
Cohort Study