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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Poor performance status is associated with early death in patients with pulmonary tuberculosis
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 100, No. 7, Year 2006
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Description
The objective of this study was to determine whether poor performance status at the start of anti-tuberculous (anti-TB) treatment is associated with early death in patients admitted to hospital with pulmonary tuberculosis (PTB). During 3 months in 2001, all adult patients admitted to eight hospitals in Limpopo Province, South Africa, and diagnosed with PTB were eligible for inclusion. At initiation of anti-TB treatment, a performance status between 0 and 4 was estimated for each patient using a modified version of the Eastern Cooperative Oncology Group scoring system. Hospital records and local TB registers were reviewed to identify patients who had died during the first 2 months of treatment. In addition, it was ascertained whether a death notification had been received by the provincial administration. Fifty-three of 295 (18%) patients died within 2 months. Mortality increased from 6% in patients with the best performance status to 51% in patients with the poorest performance status. Univariate and multivariate Cox regression analysis showed that the hazard ratio for dying was significantly higher for patients with a performance status of 3 or 4. Poor performance status shows a strong association with early death in patients with PTB and has the potential to be a useful clinical, epidemiological and research tool. © 2005 Royal Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
de Vallière, Serge
South Africa, Pietersburg
Pietersburg-mankweng Hospital Complex
Barker, Richard D.
United Kingdom, London
King's College Hospital
Statistics
Citations: 30
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1016/j.trstmh.2005.09.007
ISSN:
00359203
Research Areas
Cancer
Environmental
Health System And Policy
Infectious Diseases
Study Approach
Quantitative
Study Locations
South Africa