Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Children with endemic Burkitt lymphoma are deficient in EBNAl-specific IFN-γ T cell responses
International Journal of Cancer, Volume 124, No. 7, Year 2009
Notification
URL copied to clipboard!
Description
Endemic Burkitt lymphoma (eBL) is the most common childhood cancer in equatorial Africa and is linked to Epstein-Barr virus (EBV) and Plasmodium falciparum coinfections early in life. Epstein-Barr nuclear antigen 1 (EBNA1) is the sole viral latent antigen expressed in BL tumors. Loss of EBNAl-specific immune surveillance could allow eBL emergence. Therefore, EBNA1-specific T cell responses were analyzed by IFN-y ELISPOT in Kenyan children with eBL and compared to healthy children with divergent malaria exposure. Significantly fewer children with eBL, 16% (7/44) had EBNAl-specific IFN-y responses in contrast to healthy children living in a malaria holoendemic area or in an area with sporadic malaria transmission, 67% (40/60) and 72% (43/60) responders, respectively (p < 0.003). Children with eBL maintained IgG1 dominated antibody responses to EBNA1 similar to healthy children suggesting a selective loss of IFN-c secreting EBNA1-specific T cells in the presence of intact humoral immunity. CD8 + T cell responses to EBV lytic and latent antigens not expressed in the tumors were similarly robust in eBL patients compared to healthy children. In addition, CD4 + T cell responses to a malaria protein, merozoite surface protein 1, were present in lymphoma patients. This study demonstrates a selective loss of EBNA1-specific T cell responses in children with eBL and suggests a potential immunotherapeutic target for this EBV-associated lymphoma. © 2008 Wiley-Liss, Inc.
Authors & Co-Authors
Moormann, Ann M.
United States, Cleveland
Case School of Medicine
Heller, Kevin N.
United States, New York
Rockefeller University
Chelimo, Kiprotich
Kenya, Nairobi
Kenya Medical Research Institute
Embury, Paula B.
United States, Cleveland
Case School of Medicine
Ploutz-Snyder, Robert J.
United States, Syracuse
Suny Upstate Medical University
Otieno, Juliana A.
Kenya, Kisumu
New Nyanza Provincial General Hospital
Oduor, Margaret
Kenya, Kisumu
New Nyanza Provincial General Hospital
Münz, Christian
United States, New York
Rockefeller University
Rochford, Rosemary A.
United States, Syracuse
Suny Upstate Medical University
Statistics
Citations: 68
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1002/ijc.24014
ISSN:
00207136
e-ISSN:
10970215
Research Areas
Cancer
Infectious Diseases
Maternal And Child Health