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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Distribution of the HIV resistance CCR5-Δ32 allele among Egyptians and Syrians
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Volume 616, No. 1-2, Year 2007
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Description
A mutant allele of the β-chemokine receptor gene CCR5 bearing a 32-basepair (bp) deletion that prevents cell invasion by the primary transmitting strain of HIV-1 has recently been characterized. Individuals homozygous for the mutation are resistant to infection, even after repeated high-risk exposure, but this resistance appears not absolute, as isolated cases of HIV-positive deletion homozygotes are emerging. The consequence of the heterozygous state is not clear, but it may delay the progression to AIDS in infected individuals. In order to evaluate the frequency distribution of CCR5-Δ32 polymorphism among Egyptians, a total of 200 individuals (154 from Ismailia and 46 from Sinai) were tested. Only two heterozygous individuals from Ismailia carried the CCR5-Δ32 allele (0.6%), and no homozygous (Δ32/Δ32) individuals were detected among the tested samples. The presence of the CCR5-Δ32 allele among Egyptians may be attributed to the admixture with people of European descent. Thus we conclude that the protective deletion CCR5-Δ32 is largely absent in the Egyptian population. © 2006 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Salem, Abdel Halim
United States, Baton Rouge
Center for Biomodular Multi-scale Systems
Egypt, Ismailia
Faculty of Medicine
Batzer, Mark A.
United States, Baton Rouge
Center for Biomodular Multi-scale Systems
Statistics
Citations: 30
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1016/j.mrfmmm.2006.11.024
ISSN:
00275107
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study