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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Are variable-number tandem repeats appropriate for genotyping Mycobacterium leprae?
Journal of Clinical Microbiology, Volume 46, No. 7, Year 2008
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Description
Comparative genomics analysis of the Tamil Nadu strain of Mycobacterium leprae has uncovered several polymorphic sites with potential as epidemiological tools. In this study we compared the stability of two different markers of genomic biodiversity of M. leprae in several biopsy samples isolated from the same leprosy patient. The first type comprises five different variable-number tandem repeats (VNTR), while the second is composed of three single nucleotide polymorphisms (SNP). Contrasting results were obtained, since no variation was seen in the SNP profiles of M. leprae from 42 patients from 7 different locations in Mali whereas the VNTR profiles varied considerably. Furthermore, since variation in the VNTR pattern was seen not only between different isolates of M. leprae but also between biopsy samples from the same patient, these VNTR may be too dynamic for use as epidemiological markers for leprosy. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Monot, Marc
France, Paris
Institut Pasteur, Paris
Honoré, Nadine
France, Paris
Institut Pasteur, Paris
Balière, Charlotte
France, Paris
Institut Pasteur, Paris
Ji, Baohong
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Sow, Samba Ousmane
Mali, Bamako
Centre National D'appui à la Lutte Contre la Maladie
Brennan, Patrick Joseph
United States, Fort Collins
Colorado State University
Cole, Stewart Thomas
France, Paris
Institut Pasteur, Paris
Switzerland, Lausanne
École Polytechnique Fédérale de Lausanne
Statistics
Citations: 36
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1128/JCM.00239-08
ISSN:
00951137
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Study Locations
Mali