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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Expression of the common heat-shock protein receptor CD91 is increased on monocytes of exposed yet HIV-1-seronegative subjects
Journal of Leukocyte Biology, Volume 78, No. 1, Year 2005
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Description
The significantly higher surface expression of the surface heat-shock protein receptor CD91 on monocytes of human immunodeficiency virus type-1 (HIV-1)-infected, long-term nonprogressors suggests that HIV-1 antigen uptake and cross-presentation mediated by CD91 may contribute to host anti-HIV-1 defenses and play a role in protection against HIV-1 infection. To investigate this further, we performed phenotypic analysis to compare CD91 surface expression on CD14 monocytes derived from a cohort of HIV-1-exposed seronegative (ESN) subjects, their seropositive (SP) partners, and healthy HIV-1-unexposed seronegative (USN) subjects. The median fluorescent intensity (MFI) of CD91 on CD14+ monocytes was significantly higher in ESN compared with SP (P=0.028) or USN (P=0.007), as well as in SP compared with USN subjects (P=0.018). CD91 MFI was not normalized in SP subjects on highly active antiretroviral therapy (HAART) despite sustainable, undetectable plasma viraemia. Data in three SP subjects experiencing viral rebounds following interruption of HAART showed low CD91 MFI comparable with levels in USN subjects. There was a significant positive correlation between CD91 MFI and CD8+ T cell counts in HAART-naïve SP subjects (r=0.7, P=0.015). Increased surface expression of CD91 on CD14+ monocytes is associated with the apparent HIV-1 resistance that is observed in ESN subjects. © Society for Leukocyte Biology.
Authors & Co-Authors
Kebba, Anthony
United Kingdom, London
Chelsea and Westminster Hospital
Uganda, Entebbe
Uganda Virus Research Institute
Stebbing, Justin
United Kingdom, London
Chelsea and Westminster Hospital
Rowland, Samantha
United Kingdom, London
Chelsea and Westminster Hospital
Uganda, Entebbe
Uganda Virus Research Institute
Ingram, Rebecca J.
United Kingdom, London
Chelsea and Westminster Hospital
Uganda, Entebbe
Uganda Virus Research Institute
Agaba, John
Uganda, Entebbe
Uganda Virus Research Institute
Patterson, Steven
United Kingdom, London
Chelsea and Westminster Hospital
Kaleebu, Pontiano P.
Uganda, Entebbe
Uganda Virus Research Institute
Imami, Nesrina
United Kingdom, London
Chelsea and Westminster Hospital
Gotch, Frances M.
United Kingdom, London
Chelsea and Westminster Hospital
Statistics
Citations: 27
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1189/jlb.0105049
Research Areas
Infectious Diseases
Study Design
Cohort Study