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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Enhanced post-natal growth is associated with elevated blood pressure in young Senegalese adults
International Journal of Epidemiology, Volume 38, No. 5, Year 2009
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Description
Background: Evidence suggests that intrauterine growth restriction followed by rapid post-natal growth is associated with high blood pressure. We assessed the effect of early size and post-natal growth on blood pressure in a population from West Africa, where fetal growth retardation and childhood malnutrition are common. Methods: A total of 1288 Senegalese subjects were followed from infancy to young adulthood (mean age 17.9 years). Adult systolic blood pressure (SBP) was regressed on infant and adult anthropometric characteristics. Results: In unadjusted analyses, infant size was positively associated with adult SBP (1.1 ± 0.3; P = 0.001 for weight; 0.7 ± 0.3; P = 0.04 for length). With adjustment for current size, the regression coefficients for infant size were reversed (-0.2 ± 0.3; P = 0.51 for weight; -0.3 ± 0.3; P = 0.35 for length). SBP increased by 4.1 and 2.9 mmHg for 1 standard deviation (SD) increase in current weight or height, respectively. No interaction between infant size and current size was found in the overall models (P = 0.11 for weight, P = 0.95 for height), but this term interacted with sex for weight effect. A negative interaction was found in males (-0.9 ± 0.4; P = 0.02) but not in females (0.3 ± 0.4; P = 0.46). The association of current weight with SBP was stronger in lighter weight male infants. Conclusions: These findings support the hypothesis that subjects who were small in early life and experienced enhanced post-natal growth have higher levels of SBP, even in low-income settings. © The Author 2009; all rights reserved.
Authors & Co-Authors
Cournil, Amandine
France, Montpellier
Ird Centre de Montpellier
Coly, Aminata Ndiaye
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Diallo, Aldiouma M.
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Simondon, Kirsten Bork
France, Montpellier
Ird Centre de Montpellier
Statistics
Citations: 7
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1093/ije/dyp255
ISSN:
03005771
e-ISSN:
14643685
Research Areas
Food Security
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Participants Gender
Male
Female