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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Clinical Algorithms for the Screening of Women for Gonococcal and Chlamydial Infection: Evaluation of Pregnant Women and Prostitutes in Zaire
Clinical Infectious Diseases, Volume 17, No. 1, Year 1993
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Description
A substantial proportion of women with gonococcal and/or chlamydial infection are asymptomatic. Thus active case detection is problematical, particularly in developing countries, where facilities and materials for laboratory testing are limited. We assessed the diagnostic validity of the hierarchical clinical algorithms recommended by the World Health Organization as well as that of a nonhierarchical scoring system, using data for 1, 160 pregnant women (a low-prevalence group) and 1, 222 prostitutes (a high-prevalence group) in Kinshasa, Zaire. Neisseria gonorrhoeae and/or Chlamydia trachomatis was detected in 6.5% and 31.0% of pregnant women and prostitutes, respectively. No single variable that was both sensitive (>60%) and specific (>60%) was associated with infection. A simple hierarchical algorithm based only on reported symptoms had a sensitivity of 48.0% and 54.9% and a specificity of 75.2% and 52.2% for the screening of pregnant women and prostitutes, respectively. A second algorithm that included a speculum examination had a sensitivity of only 29.3% but a specificity of 85.3% in pregnant women. When a nonhierarchical scoring system was used, the sensitivity was 72.0% and 71.0% and the specificity was 73.5% and 55.8% for pregnant women and prostitutes, respectively. Scoring systems that incorporate risk markers as well as symptoms and signs may represent affordable alternative methods of screening for gonococcal and/or chlamydial infections among women in resource-poor settings. © 1993 by The University of Chicago.
Authors & Co-Authors
Laga, Marie W.
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
South Africa
Projet Sida Ministry of Health
Vuylsteke, Béa L.
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
South Africa
Projet Sida Ministry of Health
Alary, Michel
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
South Africa
Projet Sida Ministry of Health
Gerniers, Marie Madeleine
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
South Africa
Projet Sida Ministry of Health
Lebughe, Jean Pierre
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
South Africa
Projet Sida Ministry of Health
Nzila, N.
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
South Africa
Projet Sida Ministry of Health
Behets, Frieda M.T.F.
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
South Africa
Projet Sida Ministry of Health
van Dyck, Eddy
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
South Africa
Projet Sida Ministry of Health
Piot, Peter K.
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
South Africa
Projet Sida Ministry of Health
Statistics
Citations: 138
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1093/clinids/17.1.82
ISSN:
10584838
e-ISSN:
15376591
Study Design
Cross Sectional Study
Participants Gender
Female