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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
eBioMedicine, Volume 87, Article 104402, Year 2023
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Description
Background: Most studies of immunity to SARS-CoV-2 focus on circulating antibody, giving limited insights into mucosal defences that prevent viral replication and onward transmission. We studied nasal and plasma antibody responses one year after hospitalisation for COVID-19, including a period when SARS-CoV-2 vaccination was introduced. Methods: In this follow up study, plasma and nasosorption samples were prospectively collected from 446 adults hospitalised for COVID-19 between February 2020 and March 2021 via the ISARIC4C and PHOSP-COVID consortia. IgA and IgG responses to NP and S of ancestral SARS-CoV-2, Delta and Omicron (BA.1) variants were measured by electrochemiluminescence and compared with plasma neutralisation data. Findings: Strong and consistent nasal anti-NP and anti-S IgA responses were demonstrated, which remained elevated for nine months (p < 0.0001). Nasal and plasma anti-S IgG remained elevated for at least 12 months (p < 0.0001) with plasma neutralising titres that were raised against all variants compared to controls (p < 0.0001). Of 323 with complete data, 307 were vaccinated between 6 and 12 months; coinciding with rises in nasal and plasma IgA and IgG anti-S titres for all SARS-CoV-2 variants, although the change in nasal IgA was minimal (1.46-fold change after 10 months, p = 0.011) and the median remained below the positive threshold determined by pre-pandemic controls. Samples 12 months after admission showed no association between nasal IgA and plasma IgG anti-S responses (R = 0.05, p = 0.18), indicating that nasal IgA responses are distinct from those in plasma and minimally boosted by vaccination. Interpretation: The decline in nasal IgA responses 9 months after infection and minimal impact of subsequent vaccination may explain the lack of long-lasting nasal defence against reinfection and the limited effects of vaccination on transmission. These findings highlight the need to develop vaccines that enhance nasal immunity. Funding: This study has been supported by ISARIC4C and PHOSP-COVID consortia. ISARIC4C is supported by grants from the National Institute for Health and Care Research and the Medical Research Council. Liverpool Experimental Cancer Medicine Centre provided infrastructure support for this research. The PHOSP-COVD study is jointly funded by UK Research and Innovation and National Institute of Health and Care Research. The funders were not involved in the study design, interpretation of data or the writing of this manuscript. © 2022 The Author(s)
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC9762734/bin/mmc1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC9762734/bin/mmc2.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC9762734/bin/mmc3.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC9762734/bin/mmc4.xlsx
Authors & Co-Authors
Willett, Brian J.
United Kingdom, Glasgow
University of Glasgow
Logan, Nicola A.
United Kingdom, Glasgow
University of Glasgow
Siggins, Matthew K.
United Kingdom, London
Imperial College London
Swieboda, Dawid P.
United Kingdom, London
Imperial College London
Moore, Shona C.
United Kingdom, Liverpool
University of Liverpool
Davis, Christopher A.
United Kingdom, Glasgow
University of Glasgow
Thompson, A. A.Roger
United Kingdom, Sheffield
The University of Sheffield
Rowland-Jones, Sarah Louise
United Kingdom, Sheffield
The University of Sheffield
Docherty, Annemarie Beth
United Kingdom, Edinburgh
The University of Edinburgh
Chalmers, James D.
United Kingdom, Dundee
University of Dundee
Ho, Ling Pei
United Kingdom, Oxford
University of Oxford
Horsley, Alexander Robert
United Kingdom, Manchester
The University of Manchester
Raman, Betty
United Kingdom, Oxford
University of Oxford
Marks, Michael E.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Kon, Onn Minn
United Kingdom, London
Imperial College London
Wootton, Dan G.
United Kingdom, Liverpool
University of Liverpool
Dunachie, Susanna J.
United Kingdom, Oxford
University of Oxford
Quint, Jennifer K.
United Kingdom, London
Imperial College London
Evans, Rachael Andrea
Unknown Affiliation
Wain, Louise V.
United Kingdom, Leicester
University of Leicester
de Silva, Thushan I.
United Kingdom, Sheffield
The University of Sheffield
Ho, Antonia Ying Wai
United Kingdom, Glasgow
University of Glasgow
Harrison, Ewen M.
United Kingdom, Edinburgh
The University of Edinburgh
Baillie, John Kenneth
United Kingdom, Edinburgh
The University of Edinburgh
Semple, Malcolm Gracie
United Kingdom, Liverpool
University of Liverpool
Brightling, Christopher Edward
Unknown Affiliation
Thwaites, Ryan S.
United Kingdom, London
Imperial College London
Turtle, Lance C.W.
United Kingdom, Liverpool
University of Liverpool
Openshaw, Peter J.M.
United Kingdom, London
Imperial College London
Alex, Beatrice
Unknown Affiliation
Andrikopoulos, Petros
Unknown Affiliation
Bach, Benjamin
Unknown Affiliation
Barclay, Wendy S.
Unknown Affiliation
Bogaert, Debby (Debby)
Unknown Affiliation
Chand, Meera A.
Unknown Affiliation
Chechi, Kanta
Unknown Affiliation
Cooke, Graham S.
Unknown Affiliation
Dos Santos Correia, Gonçalo
Unknown Affiliation
Dumas, Marc Emmanuel
Unknown Affiliation
Dunning, Jake W.
Unknown Affiliation
Fletcher, Tom E.
Unknown Affiliation
Green, C. A.
Unknown Affiliation
Griffin, Julian L.
Unknown Affiliation
Gupta, Rishi K.
Unknown Affiliation
Harrison, Ewen Munro
Unknown Affiliation
Horby, Peter W.
Unknown Affiliation
Ijaz, Samreen
Unknown Affiliation
Klenerman, Paul
Unknown Affiliation
Law, Andrew S.
Unknown Affiliation
Lewis, Matthew R.
Unknown Affiliation
Liggi, Sonia
Unknown Affiliation
Maslen, Lynn
Unknown Affiliation
Mentzer, Alexander J.
Unknown Affiliation
Merson, Laura
Unknown Affiliation
Meynert, Alison M.
Unknown Affiliation
Noursadeghi, Mahdad
Unknown Affiliation
Olanipekun, Michael T.
Unknown Affiliation
Osagie, Anthonia
Unknown Affiliation
Palmarini, Massimo
Unknown Affiliation
Palmieri, Carlo
Unknown Affiliation
Paxton, William A.
Unknown Affiliation
Pollakis, Georgios P.
Unknown Affiliation
Price, Nicholas Martin
Unknown Affiliation
Rambaut, Andrew
Unknown Affiliation
Robertson, David L.
Unknown Affiliation
Russell, Clark Donald
Unknown Affiliation
Sancho-Shimizu, Vanessa
Unknown Affiliation
Sands, Caroline J.
Unknown Affiliation
Scott, Janet T.
Unknown Affiliation
Solomon, Tom
Unknown Affiliation
Sriskandan, Shiranee
Unknown Affiliation
Stuart, David Ian
Unknown Affiliation
Swann, Olivia V.
Unknown Affiliation
Takáts, Zoltán
Unknown Affiliation
Takis, Panteleimon G.
Unknown Affiliation
Tedder, Richard S.
Unknown Affiliation
Thomson, Emma C.
Unknown Affiliation
Zambon, Maria C.
Unknown Affiliation
Drake, Thomas M.
Unknown Affiliation
Fairfield, Cameron J.
Unknown Affiliation
Knight, Stephen Robert
Unknown Affiliation
McLean, Kenneth A.
Unknown Affiliation
Norman, Lisa
Unknown Affiliation
Shaw, Catherine A.
Unknown Affiliation
Gamble, C. L.
Unknown Affiliation
Girvan, Michelle
Unknown Affiliation
Jackson, Clare R.
Unknown Affiliation
Lee, James Tseryuan
Unknown Affiliation
Marsh, Laura C.
Unknown Affiliation
Plotkin, Daniel
Unknown Affiliation
Fawkes, Angie
Unknown Affiliation
Gilchrist, Tammy
Unknown Affiliation
Murphy, Lee D.
Unknown Affiliation
Wrobel, Nicola
Unknown Affiliation
Adeniji, Kayode Adebamiji
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Agranoff, Daniel D.
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Allen, Sam H.
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Angus, Brian John
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Barlow, Gavin D.
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Barrett, Nicholas A.
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Bassford, Christopher R.
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Bernatoniene, Jolanta
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Burden, Tom G.
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Chadwick, David Robert
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Collini, Paul J.
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Cosgrove, Catherine A.
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Cupitt, Jason M.
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Dark, Paul M.
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Dawson, Chris
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Dervisevic, Samir
Unknown Affiliation
Douthwaite, Sam Thomas
Unknown Affiliation
Finn, Adam H.R.
Unknown Affiliation
Fullerton, Duncan G.
Unknown Affiliation
Gkrania-Klotsas, Effrossyni
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Grammatikopoulos, Tassos
Unknown Affiliation
Hawcutt, Daniel B.
Unknown Affiliation
Howard, Jo
Unknown Affiliation
Jacobs, Michael Graham
Unknown Affiliation
Kegg, Stephen
Unknown Affiliation
Koduri, Gouri Mani
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Lillie, Patrick J.
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Lyttle, Mark David
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MacMahon, Michael
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Morgan, Patrick
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Moses, Samuel E.
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Murphy, Michael B.
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Nagarajan, Thapas
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Nelson, Mark Richard
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O'Shea, Matthew K.
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Papineni, Padmasayee
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Pepperell, Justin Charles Thane
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Peters, Mark John
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Phull, Mandeep Kaur
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Planche, Tim David
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Post, Frank A.
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Rousseau, Guy
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Schmid, Matthias Ludwig
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Sharma, Anil Kumar
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Smith, Richard A.
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Spittle, Nick
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Szakmany, Tamas
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Tatham, Kate Colette
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Thompson, Chris Vaun
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Thompson, Robert L.
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Vancheeswaran, Rama
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Wake, Rachel M.
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Welters, Ingeborg Dorothea M.
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Whitehouse, Tony
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Wilson, Lawrence Anthony
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Asiimwe, Innocent Gerald
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Brennan, Benjamin
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Clark, Jordan J.
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Cox, Helen
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Dyer, Philip H.
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Finch, Lorna S.
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García-Dorival, Isabel
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Hartley, Catherine S.
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Khandaker, Shadia
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Lant, Suzannah
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Mancini, Maria Vittoria
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McLauchlan, John H.
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Metelmann, Soeren
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Penrice-Randal, Rebekah
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Spencer, Rebecca G.
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Griffiths, Fiona
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Oosthuyzen, Wilna
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Abel, Kathryn M.
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Adeloye, Davies O.
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Adeyemi, Oluwaseun
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Ali, Mohammad I.
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Allen, Richard James
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Almeida, Paula
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Antoniades, Charalambos A.
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Baillie, Jane Kenneth
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Bain, Stephen C.
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Baldwin, David R.
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Baldwin, Matthew R.
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Ballard, Clive G.
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Batterham, Rachel Louise
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Baxendale, Helen E.
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Bayes, Hannah Kelly
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Beadsworth, Michael B.J.
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Beckett, Paul A.
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Bell, Robert M.
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Bermperi, Areti
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Bhui, Kamaldeep Singh
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Bisnauthsing, Karen N.
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Bolton, Charlotte E.
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Bramham, Kate
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Breen, Gerome
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Briggs, Andrew M.
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Brown, Anthony
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Brown, Julianne S.
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Brown, Michael M.
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Brugha, Traolach Sean
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Brunskill, N. J.
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Burn, David J.
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Burns, Gerard
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Burns, Alistair S.
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Busby, John
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Calder, Philip C.
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Carson, Gail Lindsay
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Casey, Anna L.
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Cassar, Mark Philip
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Chalder, Trudie
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Chalmers, John D.
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Channon, Keith Michael
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Chaudhuri, Nazia
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Chilvers, Edwin R.
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Chinoy, Hector
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Chiribiri, Amedeo
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Chowienczyk, Phil John
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Clohisey, Sara M.R.
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Coleman, Christopher M.
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Connolly, Bronwen A.
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Cooper, D. James
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Coupland, Carol A.C.
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Cullinan, Paul
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Cuthbertson, D. J.
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Daines, Luke
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Davies, E. Bethan
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Davies, Melanie J.
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de Soyza, Anthony
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Defres, Sylviane
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Bakerly, Nawar Diar
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Djukanovic, Ratko
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Dong, Tao
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Dormand, Natalie C.
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Easom, Nicholas J.W.
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Elliott, Angela
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Elmer, Anne
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Evans, David A.
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Felton, Tim W.
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Fisher, Helen L.
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Forton, Daniel M.
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Francis, Susan T.
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Free, Robert C.
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French, N.
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Greenhalf, William
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Hart, Nicholas
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Heaney, Liam G.
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Heightman, Melissa J.
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Heller, Simon R.
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Hosseini, Akram A.
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Hotopf, Matthew Hugo
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Hughes, Rachael A.
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Lightstone, Liz
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Lingford-Hughes, Anne R.
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Molyneaux, Philip L.
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Moss, Alastair James
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Moss, Paul A.H.
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Mukaetova-Ladinska, Elizabeta Blagoja
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Neubauer, Stefan
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Nicholson, Timothy R.
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O'Brien, Caitlin
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O'Regan, Declan P.
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Ogg, Graham Stuart
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Ostermann, Marlies Elizabeth
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Pariante, Carmine M.
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Petousi, Nayia
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Rahman, Najib Mahboob
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Reddy, Raja Vongala
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Rivera-Ortega, Pilar
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Roberts, John Keith
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Statistics
Citations: 32
Authors: 340
Affiliations: 11
Identifiers
Doi:
10.1016/j.ebiom.2022.104402
ISSN:
23523964
Research Areas
Cancer
Covid
Health System And Policy