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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Claudin-1 expression in squamous cell carcinomas of different organs: Comparative study of cancerous tissues and normal controls
International Journal of Surgical Pathology, Volume 20, No. 2, Year 2012
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Description
Claudins are the main sealing proteins of the intercellular tight junctions and play an important role in cancer cell progression and dissemination. This study examined and compared the expression of claudin-1 by immunohistochemistry in 60 squamous cell carcinomas of different tissue types and normal 33 controls, arranged in 2 tissue microarray slides. A score was generated to classify claudin-1 expression into negative, low, medium, and high. Most squamous cell carcinomas (91.67%) showed positive membranous staining. Medium to high claudin-1 expression was prevalent in carcinomas from the head-neck, skin, and genitourinary regions and was less frequent in other locations. An inverse correlation was noted between claudin-1 expression and tumor grade in tumors of the genitourinary and breast-gynecologic regions. Of the normal organs, significant claudin-1 expression was present mainly in the skin whereas other epithelial tissues had only minimal to low expression levels. Claudin-1 expression in squamous cell carcinoma varies in organ-specific manner reflecting influence of local factors and different mechanisms of claudin-1 expression. Knowledge of this fact is important in planning biologic therapy targeting claudin-1. © 2012 The Author(s).
Authors & Co-Authors
Ouban, Abderrahman
Netherlands, Saba
Saba University School of Medicine
Saudi Arabia, Al Kharj
Prince Sattam Bin Abdulaziz University
Hamdan, Hana
United States, Kansas City
Truman Medical Centers
Hakam, Ardeshir
United States, Tampa
Moffitt Cancer Center
Ahmed, Atif A.
United States, Kansas City
Children's Mercy Hospitals and Clinics
Statistics
Citations: 26
Authors: 4
Affiliations: 5
Identifiers
Doi:
10.1177/1066896911424488
ISSN:
10668969
e-ISSN:
19402465
Research Areas
Cancer