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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Fatal Plasmodium falciparum malaria causes specific patterns of splenic architectural disorganization
Infection and Immunity, Volume 73, No. 4, Year 2005
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Description
The spleen is critical for host defense against pathogens, including Plasmodium falciparum. It has a dual role, not only removing aged or antigenically altered erythrocytes from the blood but also as the major lymphoid organ for blood-borne or systemic infections. The human malaria parasite P. falciparum replicates within erythrocytes during asexual blood stages and causes repeated infections that can be associated with severe disease. In spite of the crucial role of the spleen in the innate and acquired immune response to malaria, there is little information on the pathology of the spleen in human malaria. We performed a histological and quantitative immunohistochemical study of spleen sections from Vietnamese adults dying from severe falciparum malaria and compared the findings with the findings for spleen sections from control patients and patients dying from systemic bacterial sepsis. Here we report that the white pulp in the spleens of patients dying from malaria showed a marked architectural disorganization. We observed a marked dissolution of the marginal zones with relative loss of B cells. Furthermore, we found strong HLA-DR expression on sinusoidal lining cells but downregulation on cordal macrophages. P. falciparum infection results in alterations in splenic leukocytes, many of which are not seen in sepsis. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Urban, Britta Christina
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Churchill Hospital
Hien, Tran Tinh
Viet Nam, Ho Chi Minh City
Centre for Tropical Diseases Vietnam
Day, Nichloas P.J.
United Kingdom, Oxford
University of Oxford
Thailand, Nakhon Pathom
Mahidol University
Phu, Nguyen Hoan
Viet Nam, Ho Chi Minh City
Centre for Tropical Diseases Vietnam
Roberts, Rachel
United Kingdom, Oxford
University of Oxford
Mai, Nguyen Thi Hoang
Viet Nam, Ho Chi Minh City
Centre for Tropical Diseases Vietnam
Bethell, Delia B.
Thailand, Nakhon Pathom
Mahidol University
Turner, Gareth D.H.
United Kingdom, Oxford
University of Oxford
Ferguson, David J. P.
United Kingdom, Oxford
University of Oxford
White, Nicholas J.
United Kingdom, Oxford
University of Oxford
Thailand, Nakhon Pathom
Mahidol University
Roberts, David J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Bristol
Nhs Blood and Transplant
Statistics
Citations: 102
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1128/IAI.73.4.1986-1994.2005
ISSN:
00199567
Research Areas
Infectious Diseases
Study Approach
Quantitative