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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
First Evidence of Simultaneous Circulation of Three Different Dengue Virus Serotypes in Africa
PLoS ONE, Volume 8, No. 10, Article e78030, Year 2013
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Description
Gabon, in Central Africa, was affected for the first time in 2007 and then in 2010 by simultaneous outbreaks of chikungunya and Dengue serotype 2 (DENV-2) viruses. Through the national surveillance of dengue-like syndromes between 2007 and 2010, we observed continuous circulation of DENV-2 in a southward movement. This rapid spread of DENV-2 was associated with the emergence of DENV-1 in 2007 and DENV-3 in 2010. Interestingly, we detected six DENV-2 infected patients with hemorrhagic signs during the second outbreak in 2010. Although these cases do not meet all standard WHO criteria for severe Dengue with hemorrhage (formerly DHF), this is the first report of several dengue fever cases associated with hemorrhagic signs during a simultaneous circulation of different DENV serotypes in Africa. Together, these findings suggest that DENV is becoming more widely established on this continent and that DHF will likely become a serious public-health problem in the near future. © 2013 Caron et al.
Authors & Co-Authors
Caron, Mélanie
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
France, Montpellier
Ird Centre de Montpellier
Grard, Gilda
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Paupy, Christophe
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
France, Montpellier
Ird Centre de Montpellier
Mombo, Illich Manfred
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
France, Montpellier
Ird Centre de Montpellier
Bikie Bi Nso, Branly
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Kassa-Kassa, Fabrice
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Nkoghé, Dieudonné D.
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Gabon
Ministère de la Santé Publique
Leroy, Éric Maurice
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
France, Montpellier
Ird Centre de Montpellier
Statistics
Citations: 51
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pone.0078030
e-ISSN:
19326203
Research Areas
Infectious Diseases
Study Locations
Gabon