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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Emergence of a dhfr mutation conferring high-level drug resistance in Plasmodium falciparum populations from southwest Uganda
Journal of Infectious Diseases, Volume 197, No. 11, Year 2008
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Description
The S108N, C59R, and N51I mutations in the Plasmodium falciparum gene that encodes dihydrofolate reductase, dhfr, confer resistance to pyrimethamine and are common in Africa. However, the I164L mutation, which confers high-level resistance, is rarely seen. We found a 14% prevalence of the I164L mutation among a sample of 51 patients with malaria in Kabale District in southwest Uganda in 2005 and a 4% prevalence among 72 patients with malaria in the neighboring district of Rukungiri during the same year. Surveillance at 6 sites across Uganda during 2002-2004 reported a single case of infection involving an I164L mutant, also in the southwest, suggesting that this is a regional hot spot. The spatial clustering and increasing prevalence of the I164L mutation is indicative of local transmission of the mutant. Targeted surveillance is needed to confirm the extent of the spread of the I164L mutation and to monitor the impact of I164L on the efficacy of antifolates for intermittent preventive treatment of pregnant women and/or infants with falciparum malaria. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Lynch, Caroline A.
Unknown Affiliation
Pearce, Richard J.
Unknown Affiliation
Pota, Hirva
Unknown Affiliation
Cox, Jonathan St H.
Unknown Affiliation
Abeku, Tarekegn Abose
Unknown Affiliation
Rwakimari, John Bosco
Unknown Affiliation
Naidoo, Inbarani
Unknown Affiliation
Tibenderana, James K.
Unknown Affiliation
Roper, Cally
Unknown Affiliation
Statistics
Citations: 87
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1086/587845
ISSN:
00221899
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Case Study
Study Locations
Uganda
Participants Gender
Female