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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y
Infection, Genetics and Evolution, Volume 6, No. 4, Year 2006
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Description
The choice of partner drug is critical for artemisinine-based combination therapy (ACT) to remain effective and amodiaquine (AQ) is one important candidate to evaluate. We treated 81 children <5 years with uncomplicated Plasmodium falciparum malaria with AQ alone and related the treatment outcome to the possible selection of pfcrt 76T, 152T, 163S, 326S, pfmdr1 86Y and pfmrp 191H, 437S in recurrent infections (recrudescenses and re-infections) and to the blood concentration of desethylamodiaquine (DEAQ). During 21 days follow-up 28 children had a recurrent infection (9 recrudescenses, 13 re-infections and 6 mixed). Neither genotyping of the polymorphisms before treatment nor DEAQ blood concentrations could predict treatment outcome. pfcrt 76T was however significantly selected for in recurrent infections (p = 0.020). pfmdr1 86Y was also selected for, but only in recrudescent infections (p = 0.048). The study showed high prevalence of AQ resistant parasites in vivo, which appeared to be associated to pfcrt 76T and pfmdr1 86Y. © 2005 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Holmgren, Gabrielle
Sweden, Stockholm
Karolinska Institutet
Gil, Jose Pedro
Sweden, Stockholm
Karolinska Institutet
Ferreira, Pedro Eduardo
Sweden, Stockholm
Karolinska Institutet
Portugal, Faro
Universidade do Algarve
Veiga, Maria Isabel
Sweden, Stockholm
Karolinska Institutet
Portugal, Faro
Universidade do Algarve
Obonyo, Charles O.
Kenya, Nairobi
Kenya Medical Research Institute
Bjǒrkman, Anders B.
Sweden, Stockholm
Karolinska Institutet
Statistics
Citations: 181
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.meegid.2005.09.001
ISSN:
15671348
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study