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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Tumour necrosis factor levels during acute rejection and acute tubular necrosis in renal transplant recipients
Transplant Immunology, Volume 8, No. 3, Year 2000
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Description
Plasma tumour necrosis factor levels were measured serially in 16 patients following renal transplantation, and in 10 patients on haemodialysis and in 12 patients on peritoneal dialysis. The patients on peritoneal dialysis had lower plasma TNF levels than the patients on haemodialysis. There was a decrease in TNF levels immediately following renal transplantation; this is probably related to the bolus doses of methylprednisolone administered intra-operatively. Patients with acute rejection had higher levels of TNF than non-rejecting patients. The increase in TNF levels in rejecting patients was observed 2 days before the clinical manifestation of acute rejection. There was a marked decrease in TNF levels in rejecting patients in response to treatment with steroids. Patients with delayed graft function had higher levels of TNF on the first post-operative day compared to patients with immediate function. These changes in plasma TNF levels following renal transplantation have important clinical and therapeutic implications. © 2000 Elsevier Science B.V. All rights reserved.
Authors & Co-Authors
Wiggins, M. C.
South Africa, Cape Town
University of Cape Town
Bracher, Mona
South Africa, Cape Town
University of Cape Town
Mall, Anwar Suleman
South Africa, Cape Town
University of Cape Town
Hickman, Rosemary
South Africa, Cape Town
University of Cape Town
Robson, Simon Christopher
South Africa, Cape Town
University of Cape Town
Kahn, Delawir H.
South Africa, Cape Town
University of Cape Town
South Africa, Observatory
Medical School
Statistics
Citations: 28
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/S0966-3274(00)00027-7
ISSN:
09663274
Research Areas
Cancer
Noncommunicable Diseases