Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Incident and prevalent herpes simplex virus type 2 infection increases risk of HIV acquisition among women in Uganda and Zimbabwe
AIDS, Volume 21, No. 12, Year 2007
Notification
URL copied to clipboard!
Description
BACKGROUND: An association has been demonstrated between herpes simplex type 2 (HSV-2) and HIV infection among men, but prospective studies in women have yielded mixed results. OBJECTIVE: To estimate the effects of prevalent and incident HSV-2 infection on subsequent HIV acquisition among women in two African countries. DESIGN: Prospective cohort study. METHODS: HSV-2 and HIV serostatus were evaluated at enrollment and quarterly for 15-24 months among 4531 sexually active, HIV-uninfected women aged 18-35 years from Uganda and Zimbabwe. The association between prior HSV-2 infection and HIV acquisition was estimated using a marginal structural discrete survival model, adjusted for covariates. RESULTS: HSV-2 seroprevalence at enrollment was 52% in Uganda and 53% in Zimbabwe; seroincidence during follow-up was 9.6 and 8.8/100 person-years in Uganda and Zimbabwe, respectively. In Uganda, the hazard ratio (HR) for HIV was 2.8 [95% confidence interval (CI), 1.5-5.3] among women with seroprevalent HSV-2 and 4.6 (95% CI, 1.6-13.1) among women with seroincident HSV-2, adjusted for confounding. In Zimbabwe, the HR for HIV was 4.4 (95% CI, 2.7-7.2) among women with seroprevalent HSV-2, and 8.6 (95% CI, 4.3-17.1) among women with seroincident HSV-2, adjusted for confounding. The population attributable risk percent for HIV due to prevalent and incident HSV-2 infection was 42% in Uganda and 65% in Zimbabwe. CONCLUSIONS: HSV-2 plays an important role in the acquisition of HIV among women. Efforts to implement known HSV-2 control measures, as well as identify additional measures to control HSV-2, are urgently needed to curb the spread of HIV. © 2007 Lippincott Williams & Wilkins, Inc.
Authors & Co-Authors
Brown, Joelle Morgan
United States, Los Angeles
University of California, Los Angeles
Wald, Anna
United States, Seattle
University of Washington
Hubbard, Alan E.
United States, Berkeley
University of California, Berkeley
Rungruengthanakit, Kittipong
Thailand, Chaing Mai
Chiang Mai University
Chipato, Tsungai
Zimbabwe, Harare
University of Zimbabwe
Rugpao, Sungwal
Thailand, Chaing Mai
Chiang Mai University
Mmiro, Francis A.
Uganda, Kampala
Makerere University
Celentano, David D.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Salata, Robert A.
United States, Cleveland
Case Western Reserve University
Morrison, Charles S.
United States, Durham
Clinical Research Department
Richardson, Barbra Ann
United States, Seattle
Fred Hutchinson Cancer Research Center
Padian, Nancy S.
United States, San Francisco
University of California, San Francisco
Statistics
Citations: 97
Authors: 12
Affiliations: 11
Identifiers
Doi:
10.1097/QAD.0b013e3282004929
Research Areas
Environmental
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Uganda
Zimbabwe
Participants Gender
Male
Female