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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Variant G57E of Mannose Binding Lectin associated with protection against tuberculosis caused by mycobacterium africanum but not by M. tuberculosis
PLoS ONE, Volume 6, No. 6, Article e20908, Year 2011
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Description
Structural variants of the Mannose Binding Lectin (MBL) cause quantitative and qualitative functional deficiencies, which are associated with various patterns of susceptibility to infectious diseases and other disorders. We determined genetic MBL variants in 2010 Ghanaian patients with pulmonary tuberculosis (TB) and 2346 controls and characterized the mycobacterial isolates of the patients. Assuming a recessive mode of inheritance, we found a protective association between TB and the MBL2 G57E variant (odds ratio 0.60, confidence interval 0.4-0.9, P 0.008) and the corresponding LYQC haplotype (Pcorrected 0.007) which applied, however, only to TB caused by M. africanum but not to TB caused by M. tuberculosis. In vitro, M. africanum isolates bound recombinant human MBL more efficiently than did isolates of M. tuberculosis. We conclude that MBL binding may facilitate the uptake of M. africanum by macrophages, thereby promoting infection and that selection by TB may have favoured the spread of functional MBL deficiencies in regions endemic for M. africanum. © 2011 Thye et al.
Authors & Co-Authors
Thye, Thorsten
Unknown Affiliation
Niemann, Stefan
Unknown Affiliation
Walter, Kerstin
Unknown Affiliation
Homolka, Susanne
Unknown Affiliation
Intemann, Christopher D.
Unknown Affiliation
Chinbuah, Margaret Amanua
Unknown Affiliation
Enimil, Anthony Kwame
Unknown Affiliation
Gyapong, John O.
Unknown Affiliation
Osei, Ivy Frances
Unknown Affiliation
Owusu-Dabo, Ellis
Unknown Affiliation
Rüsch-Gerdes, Sabine
Unknown Affiliation
Horstmann, Rolf Dieter
Unknown Affiliation
Ehlers, Stefan
Unknown Affiliation
Meyer, Christian G.
Unknown Affiliation
Statistics
Citations: 72
Authors: 14
Affiliations: 8
Identifiers
Doi:
10.1371/journal.pone.0020908
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Case-Control Study
Study Approach
Qualitative
Quantitative