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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Antifungal activity of limonoids from Khaya ivorensis
Pest Management Science, Volume 61, No. 2, Year 2005
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Description
Chemical investigation of the diethyl ether extract of the stem bark of Khaya ivorensis A Chev (Meliaceae) afforded ten limonoids of angolensates, ring D-opened limonoids and mexicanolides. The structures of the limonoids isolated were determined by comparison of their 1H and 13C NMR data with those reported in the literature. These compounds were evaluated for their antifungal activity against the plant pathogenic fungus Botrytis cinerea Pers. Methyl 6-hydroxyangolensate and 3,7-dideacetylkhivorin were also tested for their antifungal and antibacterial activities on several fungal and bacterial species. Methyl angolensate and 1,3,7-trideacetylkhivorin displayed the highest antifungal activity against B cinerea, with respectively 62.8 and 64.0% mycelial growth inhibition at 1000 mg litre-1, and 73.3 and 68.6% mycelial growth inhibition at 1500 mg litre-1. 3,7-Dideacetylkhivorin showed stronger antifungal and antibacterial activities than methyl 6-hydroxyangolensate against all of the test fungi and bacteria except Penicillium expansum Link. This is the first report on the antifungal and antibacterial effects of these limonoids. Structure-antifungal activity relationships of the limonoids isolated are discussed. © 2004 Society of Chemical Industry.
Authors & Co-Authors
Abdelgaleil, Samir Abdelazim Mohamed
Egypt, Alexandria
Alexandria University
Hashinaga, Fumio
Japan, Kagoshima
Kagoshima University
Nakatani, Munechiro
Japan, Kagoshima
Kagoshima University
Statistics
Citations: 76
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1002/ps.978
ISSN:
1526498X