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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria
Malaria Journal, Volume 11, Article 61, Year 2012
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Description
Background. Innate immunity plays a crucial role in the host defense against malaria including Plasmodium falciparum malaria in pregnancy, but the roles of the various underlying genes and mechanisms predisposing to the disease are poorly understood. Methods. 98 single-nucletoide polymorphisms were genotyped in a set of 17 functionally related genes of the complement system in 145 primiparous Ghanaian women with placental malaria, defined by placental parasitaemia or malaria pigment, and as a control, in 124 non-affected primiparae. Results. Placental malaria was significantly associated with SNPs in the lectin pathway genes MBL2, MASP2, FCN2 and in properdin. In particular, the main African mannose-binding lectin deficiency variant (MBL2*G57E, rs1800451) increased the odds of placental malaria (OR 1.6; permuted p-value 0.014). In contrast, a common MASP2 mutation (R439H, rs12085877), which reduces the activity of MBL-MASP2 complexes occurred in 33% of non-affected women and in 22% primiparae with placental malaria (OR 0.55, permuted p-value 0.020). Conclusions. Excessive complement activation is of importance in the pathogenesis of placental malaria by mediating inflammation, coagulation, and endothelial dysfunction. Mutated MBL and MASP2 proteins could have direct intrinsic effects on the susceptibility to placental malaria, in addition to their roles in regulation of downstream complement activation. © 2012 Holmberg et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Holmberg, Ville
Unknown Affiliation
Onkamo, Päivi
Unknown Affiliation
Lahtela, Elisa
Unknown Affiliation
Lahermo, Päivi
Unknown Affiliation
Bedu-Addo, George
Unknown Affiliation
Mockenhaupt, Frank Peter
Unknown Affiliation
Meri, Seppo K.
Unknown Affiliation
Statistics
Citations: 7
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1186/1475-2875-11-6122380611
e-ISSN:
14752875
Research Areas
Cancer
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Participants Gender
Female