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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Persistent detection of Plasmodium falciparum, P. malariae, P. ovale curtisi and P. ovale wallikeri after ACT treatment of asymptomatic Ghanaian school-children
International Journal for Parasitology: Drugs and Drug Resistance, Volume 3, Year 2013
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Description
Two hundred and seventy four asymptomatic Ghanaian school-children aged 5 to 17 years were screened for malaria parasites by examination of blood films. One hundred and fifty five microscopically-positive individuals were treated with dihydroartemisinin-piperaquine and followed for 3 weeks. Retrospective species-specific PCR of all 274 screened samples identified an additional 60 children with sub-patent parasitaemia, and a substantial proportion of co-infections with Plasmodium malariae, Plasmodium ovale curtisi and Plasmodium ovale wallikeri. One hundred individuals harboured at least one non-falciparum parasite species. Using standard double-read microscopy, the 21-day efficacy of treatment against Plasmodium falciparum was 91.4% among the 117 children seen at all 5 visits. Using nested PCR to test 152 visit 5 blood samples, 22 were found to be parasite-positive. Twenty individuals harboured P. falciparum, four harboured P. ovale spp. and two P. malariae, with four of these 22 isolates being mixed species infections. The persistent detection of low density Plasmodium sp. infections following antimalarial treatment suggests these may be a hitherto unrecognised obstacle to malaria elimination. © 2013 Australian Society for Parasitology.
Authors & Co-Authors
Dinko, Bismarck
Unknown Affiliation
Oguike, Mary Chiaka
Unknown Affiliation
Larbi, John Asiedu
Unknown Affiliation
Bousema, Teun
Unknown Affiliation
Sutherland, Colin J.
Unknown Affiliation
Statistics
Citations: 108
Authors: 5
Affiliations: 6
Identifiers
Doi:
10.1016/j.ijpddr.2013.01.001
ISSN:
22113207
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study