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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Improving second-generation surveillance: The biological measure of unprotected intercourse using prostate-specific antigen in vaginal secretions of west African women
Journal of Acquired Immune Deficiency Syndromes, Volume 42, No. 4, Year 2006
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Description
BACKGROUND: Second-generation surveillance for HIV includes measures of high-risk behaviors among the general adult population and sex workers (SW). Questionnaires are prone to social desirability biases because individuals minimize the frequency of behaviors not expected from them. OBJECTIVE: Determine whether the prostate-specific antigen (PSA) could be used as a biological marker of unprotected intercourse. METHODS: We measured the presence of PSA in vaginal secretions of women who were (n = 508) or were not (n = 658) SW presenting with vaginal discharge in health facilities of Ghana, Togo, Guinea, and Mali. The cutoff for a positive assay was determined as ≥0.4 μg/L based on a subsample of 95 non-SW claiming abstinence for 3 months. RESULTS: A positive PSA assay was correlated with infections with Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium. Among non-SW, a positive PSA was more common among those with HIV, but less frequent in those better educated. Among SW and non-SW, women from Ghana were less likely to have a positive PSA and had a lower prevalence of sexually transmitted infections than those from elsewhere. CONCLUSIONS: PSA can be used as a biological marker of unprotected intercourse, allowing interventions to target efforts on those at highest risk. Copyright © 2006 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Pépin, Jacques
Canada, Sherbrooke
Université de Sherbrooke
Canada, Sherbrooke
Centre Hospitalier Universitaire de Sherbrooke
Fink, Guy D.
Canada, Sherbrooke
Centre Hospitalier Universitaire de Sherbrooke
Khonde, Nzambi
Ghana, Accra
West Africa Project to Combat Aids
Sobéla, François
Ghana, Accra
West Africa Project to Combat Aids
Deslandes, Sylvie
Canada, Sherbrooke
Université de Sherbrooke
Diakité, Soumaïla Laye
Ghana, Accra
West Africa Project to Combat Aids
Labbé, Annie Claude
Canada, Montreal
Hôpital Maisonneuve-rosemont
Sylla, Mohamed
Ghana, Accra
West Africa Project to Combat Aids
Frost, Eric Harold E.
Canada, Sherbrooke
Université de Sherbrooke
Statistics
Citations: 11
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1097/01.qai.0000222286.52084.9c
ISSN:
15254135
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Study Locations
Ghana
Guinea
Mali
Togo
Participants Gender
Female