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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine
Bioorganic and Medicinal Chemistry Letters, Volume 11, No. 19, Year 2001
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Description
Sulfonamide and urea derivatives of quinacrine with varying methylene spacer lengths were synthesised and tested for inhibition of trypanothione reductase (TryR) and for activity in vitro against strains of the parasitic protozoa Trypanosoma, Leishmania, and Plasmodium. These derivatives are superior inhibitors of TryR relative to quinacrine with the best compound being 40 times more potent. Urea derivatives generally displayed good in vitro activity against all parasites. © 2001 Elsevier Science Ltd. All rights reserved.
Authors & Co-Authors
Chibale, Kelly
Unknown Affiliation
Haupt, Hayley
Unknown Affiliation
Kendrick, H.
Unknown Affiliation
Yardley, Vanessa
Unknown Affiliation
Saravanamuthu, Ahilan
Unknown Affiliation
Fairlamb, Alan H.
Unknown Affiliation
Croft, S. L.
Unknown Affiliation
Statistics
Citations: 80
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/S0960-894X(01)00528-5
ISSN:
0960894X