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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
High heritability of antimycobacterial immunity in an area of hyperendemicity for tuberculosis disease
Journal of Infectious Diseases, Volume 201, No. 1, Year 2010
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Description
Human antimycobacterial immunity is a critical component of tuberculosis (TB) pathogenesis that is often used to infer the presence of TB infection. We report high heritability (>50%) for in vitro secretion of tumor necrosis factor α and interferon γ (IFN-γ), and the frequency of antigen-specific IFN-γ +CD4 + and IFN- γ +CD8 + cells in the response of whole blood to mycobacterial challenge. In principal component analysis, the first 3 components explain 78% of the overall variance consistent with the effect of pleiotropic regulatory genes of human antimycobacterial immunity. These results directly demonstrate the pivotal role played by host genetics in quantitative measures of antimycobacterial immunity underlying immune diagnosis of TB infection. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Cobat, Aurélie
France, Paris
Inserm
France, Paris
Université Paris Cité
Gallant, Caroline Julie
Canada, Montreal
Université Mcgill
Simkin, Leah
Canada, Montreal
Université Mcgill
Black, Gillian Frances
Denmark, Copenhagen
Det Sundhedsvidenskabelige Fakultet
Stanley, Kim
Denmark, Copenhagen
Det Sundhedsvidenskabelige Fakultet
Hughes, Jane E.
South Africa, Cape Town
Faculty of Health Sciences
Mark Doherty, T.
Denmark, Copenhagen
Statens Serum Institut
Hanekom, Willem Albert
South Africa, Cape Town
Faculty of Health Sciences
Eley, Brian S.
South Africa, Cape Town
University of Cape Town
Beyers, Nulda
South Africa, Stellenbosch
Stellenbosch University
Jaïs, Jean Philippe
France, Paris
Université Paris Cité
Van Helden, Paul D.
Denmark, Copenhagen
Det Sundhedsvidenskabelige Fakultet
Abel, Laurent
France, Paris
Inserm
France, Paris
Université Paris Cité
United States, New York
Rockefeller University
Hoal, Eileen G.
Denmark, Copenhagen
Det Sundhedsvidenskabelige Fakultet
Alcaïs, Alexandre
France, Paris
Inserm
France, Paris
Université Paris Cité
United States, New York
Rockefeller University
Schurr, Erwin
Canada, Montreal
Université Mcgill
Canada, Montreal
Mcgill University Health Centre, Montreal General Hospital
Statistics
Citations: 59
Authors: 16
Affiliations: 10
Identifiers
Doi:
10.1086/648611
ISSN:
00221899
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Approach
Quantitative