Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Hepatitis B virus infection among HIV-infected pregnant women in Malawi and transmission to infants
Journal of Hepatology, Volume 60, No. 3, Year 2014
Notification
URL copied to clipboard!
Description
Background & Aims The extent of HBV infection to infants of HBV/HIV-coinfected pregnant women in sub-Saharan Africa is unknown. The aim of this study was to assess prevalence of HBV infection among antiretroviral- naïve, HIV-infected pregnant women in Malawi and examine HBV transmission to their infants. Methods Plasma from 2048 HIV-infected, Malawian women and their infants were tested for markers of HBV infection. Study participants were provided standard-of-care health services, which included administration of pentavalent vaccine to infants at 6, 10, and 14 weeks of age. Results One-hundred and three women (5%) were HBsAg-positive; 70 of these HBsAg-positive women were also HBV-DNA-positive. Sixteen women (0.8%) were HBV-DNA-positive but HBsAg-negative. Five of 51 infants (9.8%) born to HBsAg-positive and/or HBV-DNA-positive women were HBV-DNA-positive by 48 weeks of age. HBV DNA concentrations of two infants of mothers who received extended lamivudine-containing anti-HIV prophylaxis were <4 log10 IU/ml compared to ≥8 log10 IU/ml in three infants of mothers who did not. Conclusions HBV DNA was detected in nearly 10% of infants born to HBV/HIV-coinfected women. Antenatal testing for HIV and HBV, if instituted, can facilitate implementation of prophylactic measures against infant infection by both viruses. © 2013 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Authors & Co-Authors
Chasela, Charles S.
Malawi, Lilongwe
Unc Project-malawi
Ireland, Dublin
University College Dublin
Kourtis, Athena P.
United States, Atlanta
National Center for Chronic Disease Prevention and Health Promotion
Wall, Patrick
Ireland, Dublin
University College Dublin
Drobeniuc, Jan
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
King, Caroline C.
United States, Atlanta
National Center for Chronic Disease Prevention and Health Promotion
Thai, Hong T.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Teshale, Eyasu Habtu
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Hosseinipour, Mina C.
Malawi, Lilongwe
Unc Project-malawi
United States, Chapel Hill
Unc School of Medicine
Ellington, Sascha R.
United States, Atlanta
National Center for Chronic Disease Prevention and Health Promotion
Codd, Mary B.
Ireland, Dublin
University College Dublin
Jamieson, Denise J.
United States, Atlanta
National Center for Chronic Disease Prevention and Health Promotion
Knight, Rodney J.
United States, Rockville
Westat, Inc.
Fitzpatrick, Patricia
Ireland, Dublin
University College Dublin
Kamili, Saleem
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Hoffman, Irving F.
United States, Chapel Hill
Unc School of Medicine
Kayira, Dumbani
Malawi, Lilongwe
Unc Project-malawi
Mumba, Noel
Malawi, Lilongwe
Unc Project-malawi
Kamwendo, Deborah D.
Malawi, Lilongwe
Unc Project-malawi
Martinson, Francis E.A.
Malawi, Lilongwe
Unc Project-malawi
Powderly, William G.
Ireland, Dublin
University College Dublin
Teo, Chong Gee
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
van der Horst, Charles Michael
United States, Chapel Hill
Unc School of Medicine
Statistics
Citations: 36
Authors: 22
Affiliations: 6
Identifiers
Doi:
10.1016/j.jhep.2013.10.029
ISSN:
01688278
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Malawi
Participants Gender
Female