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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
CAG repeat length in androgen receptor gene and male infertility in Egyptian patients
Andrologia, Volume 44, No. 1, Year 2012
Notification
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Description
The CAG repeat and its association with infertility has been debatable. Therefore, this study was planned to assess the distribution of CAG repeat expansion in Egyptian patients and to investigate its association with male infertility. Forty-five infertile men were eligible for the study in addition to 20 aged-matched fertile males as control. Semen analysis, scrotal sonography, assay of serum testosterone, follicle-stimulating hormone (FSH) and luteinising hormone (LH), and determination of the CAG repeat number within exon 1 of the androgen receptor (AR) gene were carried out. Statistically significant difference was found between infertile and control groups regarding sperm count, sperm motility, serum FSH level and CAG repeats (P<0.05); statistically insignificant difference for the CAG repeats (P=1.0) was found between oligozoospermic and asthenospermic groups; negative correlation was found between CAG repeat length and sperm count, and a positive correlation was found between CAG repeat length and serum FSH (P<0.05). Our results validate the concept that long stretches of CAG repeat may be associated with lower AR function with derangement of sperm production, and this may contribute to male infertility in Egyptian men. © 2011 Blackwell Verlag GmbH.
Authors & Co-Authors
Mosaad, Y. M.
Egypt, Mansoura
Faculty of Medicine
Shahin, Doaa Abd ELhaliem
Egypt, Mansoura
Faculty of Medicine
Elkholy, Ayman A.M.
Egypt, Mansoura
Faculty of Medicine
Mosbah, Ahmed
Egypt, Mansoura
Faculty of Medicine
Badawy, W.
Egypt, Mansoura
Students Hospital
Statistics
Citations: 28
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1111/j.1439-0272.2010.01100.x
ISSN:
03034569
e-ISSN:
14390272
Research Areas
Genetics And Genomics
Sexual And Reproductive Health
Participants Gender
Male