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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Identification of oxadiazoles as new drug leads for the control of schistosomiasis
Nature Medicine, Volume 14, No. 4, Year 2008
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Description
Treatment for schistosomiasis, which is responsible for more than 280,000 deaths annually, depends almost exclusively on praziquantel. Millions of people are treated annually with praziquantel, and drug-resistant parasites thus are likely to evolve. Phosphinic amides and oxadiazole 2-oxides, identified from a quantitative high-throughput screen, were shown to inhibit a parasite enzyme, thioredoxin glutathione reductase (TGR), with activities in the low micromolar to low nanomolar range. Incubation of parasites with these compounds led to rapid inhibition of TGR activity and parasite death. The activity of the oxadiazole 2-oxides was associated with a donation of nitric oxide. Treatment of schistosome-infected mice with 4-phenyl-1,2,5-oxadiazole-3-carbonitrile-2-oxide led to marked reductions in worm burdens from treatments against multiple parasite stages and egg-associated pathologies. The compound was active against the three major schistosome species infecting humans. These protective effects exceed benchmark activity criteria set by the World Health Organization for lead compound development for schistosomiasis. © 2008 Nature Publishing Group.
Authors & Co-Authors
Sayed, Ahmed Abdel Aziz
United States, Chicago
Illinois State University
Simeonov, Anton
United States, Bethesda
National Institutes of Health Nih
Thomas, Craig J.
United States, Bethesda
National Institutes of Health Nih
Inglese, J.
United States, Bethesda
National Institutes of Health Nih
Austin, Christopher P.
United States, Bethesda
National Institutes of Health Nih
Williams, David Lee
United States, Chicago
Illinois State University
Statistics
Citations: 259
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1038/nm1737
ISSN:
1546170X
Research Areas
Infectious Diseases
Study Approach
Quantitative