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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Juvenile and adult onset systemic lupus erythematosus outcome in Egyptian patients
Egyptian Rheumatologist, Volume 33, No. 2, Year 2011
Notification
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Description
Aim of the work: The aim was to study the outcome characteristics of systemic lupus erythematosus (SLE) in Egyptians according to the age at disease onset and gender. Patients and methods: We studied 239 SLE patients (185 adult and 54 Juvenile onset) with a female to male ratio of 9.39-1 and a mean age of 28.23 ± 8.91. years and disease duration of 5.45 ± 4.25. years. Full history taking, thorough clinical examination, laboratory and relevant radiological investigations were performed. Disease activity was assessed using SLEDAI and damage by SLICC. Renal biopsies were done in those with renal involvement. Results: The clinical manifestations, disease activity and damage and laboratory investigations of the SLE patients varied according to the age at disease onset and gender. The prevalence of damage was obviously increased in juvenile patients and higher in males. Growth failure, delayed puberty and fibromyalgia were present more in Juvenile-onset patients. Adult onset SLE patients had a significantly higher secondary Sjögren syndrome especially in females. In the present study, there was a 2.5% mortality and the commonly involved kidneys were an important cause of death. Conclusion: Measuring organ damage in SLE is important with special concern to juvenile-onset patients to allow for designing new treatments that improve control of disease activity and minimize the development of irreversible damage. The kidney appeared to be commonly involved, especially in males, indicating the importance of regular screening for early and appropriate management. © 2011.
Authors & Co-Authors
A Gheita, Tamer
Egypt, Cairo
Faculty of Medicine
Fawzy, Samar Mohamed
Egypt, Cairo
Faculty of Medicine
El Baky, Abeer M.Nour El Din Abd
Egypt, Giza
National Research Centre
El-Fishawy, Hussein Saeed
Egypt, Cairo
Faculty of Medicine
Statistics
Citations: 43
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/j.ejr.2011.03.006
ISSN:
11101164
e-ISSN:
20902433
Study Design
Cross Sectional Study
Participants Gender
Male
Female