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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Summary of guidelines for managing histoplasmosis among people living with HIV
Journal of Fungi, Volume 7, No. 2, Article 134, Year 2021
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Description
Histoplasmosis is a frequent fungal opportunistic infection in people living with HIV (PLHIV), associated every year to a total of 5% to 15% of AIDS-related deaths among this population. In 2020, the first global guidelines for diagnosing and managing disseminated histoplasmosis among PLHIV was published. This document recommends (1) detection of circulating Histoplasma antigens as the recommended laboratory assay to diagnose histoplasmosis among PLHIV; (2) the use of liposomal amphotericin for induction therapy in severe or moderately severe disease, followed by a maintenance therapy with itraconazole for 12 months; a shorter maintenance therapy could be considered if the patient is clinically stable and if immune status has improved; (3) antiretroviral therapy initiation as soon as possible among patients with histoplasmosis without involvement of central nervous system; and (4) that for the treatment of co-infection with histoplasmosis and tuberculosis (TB), treatment of TB should be initiated according to theWorld Health Organization treatment guidelines. Appropriate health education of providers, supportive supervision, and policy guidance for the care of PLHIV are required. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Authors & Co-Authors
Pérez, Freddy
United States, Washington, D.c.
Pan American Health Organization
Ford, Nathan P.
Switzerland, Geneva
Organisation Mondiale de la Santé
Ravasi, Giovanni
United States, Washington, D.c.
Pan American Health Organization
Gómez, Beatriz L.
Colombia, Bogota
Universidad Del Rosario
Pasqualotto, Alessandro C.
Brazil, Porto Alegre
Universidade Federal de Ciencias da Saúde de Porto Alegre
Hine, Paul Mike
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Adenis, Antoine A.
France, Paris
Inserm
Nacher, Mathieu
France, Paris
Inserm
Chiller, Tom M.
United States, Atlanta
Centers for Disease Control and Prevention
Baddley, John W.
United States, Baltimore
University of Maryland School of Medicine
Statistics
Citations: 13
Authors: 10
Affiliations: 9
Identifiers
Doi:
10.3390/jof7020134
ISSN:
2309608X
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study