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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Successful co-administration of a human rotavirus and oral poliovirus vaccines in Bangladeshi infants in a 2-dose schedule at 12 and 16 weeks of age
Vaccine, Volume 27, No. 9, Year 2009
Notification
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Description
Co-administration of oral live-attenuated human rotavirus vaccine RIX4414 (Rotarix™) and oral polio vaccine (OPV) was assessed. Healthy infants were randomised to receive 2-doses of either: RIX4414 or placebo co-administered with OPV (12 and 16 weeks of age); or RIX4414 or placebo given 15 days after OPV. After vaccination, 56.5-66.7% of RIX4414 and 18.6% of placebo recipients had seroconverted for rotavirus IgA. No significant differences between RIX4414 groups with or without OPV co-administration were observed. No statistically significant differences were observed between groups for polio seroprotection rates. RIX4414 vaccine was immunogenic when co-administered with OPV and did not interfere with OPV seroprotection rates. © 2009 Elsevier Ltd.
Authors & Co-Authors
Zaman, Khalequzzaman S.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Sack, David Allen
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Yunus, Mohammad Faisal Mohammed
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Arifeen, Shams El I.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Podder, Goutam
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Azim, Tasnim
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Luby, Stephen P.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Breiman, Robert F.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Neuzil, Kathleen Maletic
United States, Seattle
Path Seattle
Delem, Andŕee D.
Belgium, Rixensart
Glaxosmithkline Biologicals S.a.
Suryakiran, Pemmaraju Venkata
Belgium, Rixensart
Glaxosmithkline Biologicals S.a.
Bock, Hans Ludwig
Belgium, Rixensart
Glaxosmithkline Biologicals S.a.
Statistics
Citations: 100
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1016/j.vaccine.2008.12.059
ISSN:
0264410X
Research Areas
Health System And Policy