Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The half-life of maternal transplacental antibodies against diphtheria, tetanus, and pertussis in infants: an individual participant data meta-analysis
Vaccine, Volume 40, No. 3, Year 2022
Notification
URL copied to clipboard!
Description
Aim: There are few reliable estimates of the half-lives of maternal antibodies to the antigens found in the primary series vaccines. We aimed to calculate the half-lives of passively acquired diphtheria, tetanus and pertussis (DTP) antibodies in infants. We aimed to determine whether decay rates varied according to country, maternal age, gestational age, birthweight, World Bank income classifications, or vaccine received by the mother during pregnancy. Methods: De-identified data from infants born to women taking part in 10 studies, in 9 countries (UK, Belgium, Thailand, Vietnam, Canada, Pakistan, USA, Guatemala and the Netherlands) were combined in an individual participant data meta-analysis. Blood samples were taken at two timepoints before any DTP-containing vaccines were received by the infant: at birth and at 2-months of age. Decay rates for each antigen were log2-transformed and a mixed effects model was applied. Half-lives were calculated by taking the reciprocal of the absolute value of the mean decay rates. Results: Data from 1426 mother-infant pairs were included in the analysis. The half-lives of the 6 antigen-specific maternal antibodies of interest were similar, with point estimates ranging from 28.7 (95% CI: 24.4 – 35) days for tetanus toxoid antibodies to 35.1 (95% CI: 30.7 – 41.1) days for pertactin antibodies. The decay of maternal antibodies did not significantly differ by maternal age, gestational age, birthweight, maternal vaccination status or type of vaccine administered. Conclusion: Maternal antibodies decay at different rates for the different antigens; however, the magnitude of the difference is small. Decay rates are not modified by key demographic or vaccine characteristics. © 2021
Authors & Co-Authors
Oguti, Blanché
United Kingdom, Oxford
University of Oxford
Ali, Asad S.
Pakistan, Karachi
The Aga Khan University
Andrews, N. J.
United Kingdom, London
Public Health England
Halperin, Scott A.
Canada, Halifax
Canadian Center for Vaccinology
Holder, Beth
United Kingdom, London
Imperial College London
Kampmann, Beate B.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Kazi, Abdul Momin
Pakistan, Karachi
The Aga Khan University
Langley, Joanne M.
Canada, Halifax
Canadian Center for Vaccinology
Leuridan, Elke
Belgium, Antwerpen
Universiteit Antwerpen
Miller, Elizabeth
United Kingdom, London
Public Health England
Omer, Saad B.
United States, Yale
Yale Institute for Global Health
Pollard, Andrew J.
United Kingdom, Oxford
University of Oxford
Rice, Thomas F.
United Kingdom, London
Imperial College London
Rots, Nynke Y.
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Sundaram, Maria E.
United States, Marshfield
Marshfield Clinic
Wanlapakorn, Nasamon
Thailand, Bangkok
Chulalongkorn University
Voysey, Merryn
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 7
Authors: 17
Affiliations: 14
Identifiers
Doi:
10.1016/j.vaccine.2021.12.007
ISSN:
0264410X
Research Areas
Maternal And Child Health
Sexual And Reproductive Health
Study Approach
Systematic review
Participants Gender
Female