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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Stakeholder perspectives on ethical challenges in hiv vaccine trials in South Africa
Developing World Bioethics, Volume 10, No. 1, Year 2010
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Description
There is little published literature on the ethical concerns of stakeholders in HIV vaccine trials. This study explored the ethical challenges identified by various stakeholders, through an open-ended, in-depth approach. While the few previous studies have been largely quantitative, respondents in this study had the opportunity to spontaneously identify the issues that they perceived to be of priority concern in the South African context. Stakeholders spontaneously identified the following as ethical priorities: informed consent, social harms, collaborative relationships between research stakeholders, the participation of children and adolescents, access to treatment for participants who become infected with HIV, physical harms, fair participant and community selection, confidentiality, benefits, and payment.While there is some speculation that research in developing countries poses special ethical challenges, overall no issues were identified that have not been anticipated in international guidance, literature and popular frameworks. However, the South African context affords a distinctive gloss to these expected issues; for example, respondents were concerned that the predominant selection of black participants may perpetuate racist practices of apartheid. Stakeholders should be aware of contextual factors impacting on the implementation of ethical principles. We make a series of recommendations for South African trials, including amendments to the ethical-legal framework and research policies, and, for further research. © 2009 Blackwell Publishing Ltd.
Authors & Co-Authors
Essack, Zaynab
South Africa, Durban
University of Kwazulu-natal
Koen, Jennifer
South Africa, Durban
University of Kwazulu-natal
Barsdorf, Nicola Wendy
South Africa, Durban
University of Kwazulu-natal
Slack, Catherine M.
South Africa, Durban
University of Kwazulu-natal
Quayle, Michael
South Africa, Durban
University of Kwazulu-natal
Milford, Cecilia
South Africa, Johannesburg
Reproductive Health and Hiv Research Unit (rhru)
Lindegger, Graham Charles
South Africa, Durban
University of Kwazulu-natal
Ranchod, Chitra
South Africa, Overport
Human Sciences Research Council Hsrc
Mukuka, Richard
South Africa, Durban
University of Kwazulu-natal
Statistics
Citations: 44
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1111/j.1471-8847.2009.00254.x
ISSN:
14718731
e-ISSN:
14718847
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Approach
Qualitative
Quantitative
Study Locations
South Africa