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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
computer science
Automated MRI-Based Deep Learning Model for Detection of Alzheimer's Disease Process
International Journal of Neural Systems, Volume 30, No. 6, Article 2050032, Year 2020
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Description
In the context of neuro-pathological disorders, neuroimaging has been widely accepted as a clinical tool for diagnosing patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). The advanced deep learning method, a novel brain imaging technique, was applied in this study to evaluate its contribution to improving the diagnostic accuracy of AD. Three-dimensional convolutional neural networks (3D-CNNs) were applied with magnetic resonance imaging (MRI) to execute binary and ternary disease classification models. The dataset from the Alzheimer's disease neuroimaging initiative (ADNI) was used to compare the deep learning performances across 3D-CNN, 3D-CNN-support vector machine (SVM) and two-dimensional (2D)-CNN models. The outcomes of accuracy with ternary classification for 2D-CNN, 3D-CNN and 3D-CNN-SVM were 82.57 ± 7.35%, 89.76 ± 8.67% and 95.74 ± 2.31% respectively. The 3D-CNN-SVM yielded a ternary classification accuracy of 93.71%, 96.82% and 96.73% for NC, MCI and AD diagnoses, respectively. Furthermore, 3D-CNN-SVM showed the best performance for binary classification. Our study indicated that 'NC versus MCI' showed accuracy, sensitivity and specificity of 98.90%, 98.90% and 98.80%; 'NC versus AD' showed accuracy, sensitivity and specificity of 99.10%, 99.80% and 98.40%; and 'MCI versus AD' showed accuracy, sensitivity and specificity of 89.40%, 86.70% and 84.00%, respectively. This study clearly demonstrates that 3D-CNN-SVM yields better performance with MRI compared to currently utilized deep learning methods. In addition, 3D-CNN-SVM proved to be efficient without having to manually perform any prior feature extraction and is totally independent of the variability of imaging protocols and scanners. This suggests that it can potentially be exploited by untrained operators and extended to virtual patient imaging data. Furthermore, owing to the safety, noninvasiveness and nonirradiative properties of the MRI modality, 3D-CNN-SMV may serve as an effective screening option for AD in the general population. This study holds value in distinguishing AD and MCI subjects from normal controls and to improve value-based care of patients in clinical practice. © 2020 World Scientific Publishing Company.
Authors & Co-Authors
Feng, Wei
China, Beijing
Capital Medical University
Mesregah, Mohamed Kamal
United States, Los Angeles
Keck School of Medicine of Usc
Statistics
Citations: 92
Authors: 2
Affiliations: 4
Identifiers
Doi:
10.1142/S012906572050032X
ISSN:
01290657
Research Areas
Health System And Policy
Study Design
Cross Sectional Study